Key Product Details

Validated by

Knockout/Knockdown

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Knockdown Validated, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # TAO1 1.2

Format

BSA Free

Concentration

1 mg/ml

View all TAO Kinase 1 Antibodies »

Product Specifications

Immunogen

His-tagged recombinant human TAO Kinase 1 (722-1001) generated in E.coli

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Theoretical MW

120 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

Clone also known as TAO_1.2_VMD

Scientific Data Images for TAO Kinase 1 Antibody (TAO1 1.2) - BSA Free

Western Blot: TAO Kinase 1 Antibody (TAO1 1.2) [NBP2-50324] -

Western Blot: TAO Kinase 1 Antibody (TAO1 1.2) [NBP2-50324] - HeLa cells were transfected with Negative control siRNA (Neg) or TAO1 siRNAs to assess the extent of protein depletion

Applications for TAO Kinase 1 Antibody (TAO1 1.2) - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:10 - 1:500

Western Blot

1:100 - 1:2000
Application Notes
Staining Pattern: Cellular Cortex. Positive control(s): Lysate from HeLa cell line.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TAO Kinase 1

TAOK1, a member of the Ste20 kinase family, is a TAO type protein kinase that acts as an upstream activator to MARK by phosphorylation. When activated, MARK enhances microtubule dynamics and leads to phosphorylation and detachment of tau or equivalent MAPs from microtubules. Overexpression of MARK eventually leads to microtubule breakdown and cell death, but in neuronal cells the primary effect is to allow the development of neurites during differentiation.

Long Name

Serine/threonine-protein kinase TAO1

Alternate Names

hKFC-B, hTAOK1, KIAA1361, MAP3K16, MARK Kinase, MARKK, PSK-2, PSK2, TAOK1

Gene Symbol

TAOK1

Additional TAO Kinase 1 Products

Product Documents for TAO Kinase 1 Antibody (TAO1 1.2) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for TAO Kinase 1 Antibody (TAO1 1.2) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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