TEM7/PLXDC1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-86954

Novus Biologicals, part of Bio-Techne
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NBP1-86954
NBP1-86954-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all TEM7/PLXDC1 Antibodies »

Product Summary for TEM7/PLXDC1 Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: RSCDACMSSDLTFNCSWCHVLQRCSSGFDRYRQEWMDYGCAQEAEGRMCEDFQDEDHDSASPDTSFSPYDGDLTTTSSSLFIDSLTTEDDTKLNPYAGGDGLQNNLSPKTKGTPVHLG

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (81%), Rat (83%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TEM7/PLXDC1 Antibody

Immunohistochemistry-Paraffin: TEM7/PLXDC1 Antibody [NBP1-86954]

Immunohistochemistry-Paraffin: TEM7/PLXDC1 Antibody [NBP1-86954]

Immunohistochemistry-Paraffin: TEM7/PLXDC1 Antibody [NBP1-86954] - Staining of human colorectal cancer shows strong membranous positivity in endothelial cells.
Immunohistochemistry-Paraffin: TEM7/PLXDC1 Antibody [NBP1-86954]

Immunohistochemistry-Paraffin: TEM7/PLXDC1 Antibody [NBP1-86954]

Immunohistochemistry-Paraffin: TEM7/PLXDC1 Antibody [NBP1-86954] - Staining of human skeletal muscle shows no positivity in striated muscle fibers as expected. Endothelial cells are positive.
Immunohistochemistry-Paraffin: TEM7/PLXDC1 Antibody [NBP1-86954]

Immunohistochemistry-Paraffin: TEM7/PLXDC1 Antibody [NBP1-86954]

Immunohistochemistry-Paraffin: TEM7/PLXDC1 Antibody [NBP1-86954] - Staining of human kidney shows moderate to strong membranous positivity in endothelial cells of blood vessels and renal glomeruli.
View 1 more images

Applications for TEM7/PLXDC1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TEM7/PLXDC1

Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.

Long Name

Tumor Endothelial Marker 7/Plexin Domain Containing Protein 1

Alternate Names

PLXDC1, TEM3

Gene Symbol

PLXDC1

Additional TEM7/PLXDC1 Products

Product Documents for TEM7/PLXDC1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TEM7/PLXDC1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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