TGF-beta RII Antibody (SR2244)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21740

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21740-100ul
NBP3-21740-50ul
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2244

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TGF-beta RII Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human TGF-beta RII (Uniprot #: P37173)

Specificity

Detects endogenous levels of total TGF-beta RII

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

80 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for TGF-beta RII Antibody (SR2244)

Western Blot: TGF-beta RII Antibody (SR2244) [NBP3-21740] -

Western Blot: TGF-beta RII Antibody (SR2244) [NBP3-21740] - Western blot analysis using NBP3-21740 in A549 cell lysate.

Applications for TGF-beta RII Antibody (SR2244)

Application
Recommended Usage

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TGF-beta RII

TGF beta Receptor II is a total of three members of the TGFbeta family, TGFbeta1, TGFbeta2 and TGFbeta3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFbetas mediate their activity by high affinity binding to the type II receptor (TGFbeta RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. For signaling growth inhibition and early gene responses the type II receptor requires both its kinase activity and association with a TGFbeta-binding protein, designated the type I receptor. Two independent groups have recently described the cloning and sequence analysis of genes encoding TGFbeta type I receptor proteins designated ALK-5 (TbetaR-1) and TSR-1, respectively.

Long Name

Transforming Growth Factor beta Receptor II

Alternate Names

TGF-bRII, TGFbetaRII, TGFBR2

Gene Symbol

TGFBR2

Additional TGF-beta RII Products

Product Documents for TGF-beta RII Antibody (SR2244)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TGF-beta RII Antibody (SR2244)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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