TIMP-2 Antibody (OTI1A6)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-01573

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Canine, Monkey

Cited:

Human

Applications

Validated:

Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # OTI1A6

Concentration

1 mg/ml

View all TIMP-2 Antibodies »

Product Specifications

Immunogen

Full length human recombinant protein of human TIMP2(NP_003246) produced in HEK293T cell.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

21.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for TIMP-2 Antibody (OTI1A6)

Western Blot: TIMP-2 Antibody (OTI1A6) [NBP2-01573]

Western Blot: TIMP-2 Antibody (OTI1A6) [NBP2-01573]

Western Blot: TIMP2 Antibody (1A6) [NBP2-01573] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TIMP2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TIMP2.
Immunohistochemistry-Paraffin: TIMP-2 Antibody (OTI1A6) [NBP2-01573]

Immunohistochemistry-Paraffin: TIMP-2 Antibody (OTI1A6) [NBP2-01573]

Immunohistochemistry-Paraffin: TIMP2 Antibody (1A6) [NBP2-01573] - Staining of paraffin-embedded Human pancreas tissue using anti-TIMP2 mouse monoclonal antibody.
Flow Cytometry: TIMP-2 Antibody (OTI1A6) [NBP2-01573]

Flow Cytometry: TIMP-2 Antibody (OTI1A6) [NBP2-01573]

Flow Cytometry: TIMP2 Antibody (1A6) [NBP2-01573] - HEK293T cells transfected with either overexpression plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-TIMP2 antibody, and then analyzed by flow cytometry.
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Applications for TIMP-2 Antibody (OTI1A6)

Application
Recommended Usage

Flow Cytometry

1:100

Immunohistochemistry

1:150

Immunohistochemistry-Paraffin

1:150

Western Blot

1:500-2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.3), 1.0% BSA and 50% Glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: TIMP-2

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq].

Long Name

Tissue Inhibitors of Metalloproteinases 2

Alternate Names

TIMP2

Entrez Gene IDs

7077 (Human)

Gene Symbol

TIMP2

Additional TIMP-2 Products

Product Documents for TIMP-2 Antibody (OTI1A6)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TIMP-2 Antibody (OTI1A6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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