Immunogen displays the following percentage of sequence identity for non-tested species: crab-eating macaque (98%). Mouse reactivity reported in scientific literature (PMID: 30594810).

Localization

Membrane; Multi-pass membrane protein

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for TMEM97 Antibody [DyLight 405]

Application

Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: TMEM97

TMEM97 (transmembrane protein 97 or protein MAC30) is a member of IGFBP/insulin-like growth factor-binding protein family and is implicated in several biological processes wherein it acts through its regulatory effects on IGF activity. It is a multi-pass membrane protein which is localized in nuclear and cell membranes, RER and lysosomes, and is expressed in several normal tissues including brain, lung, heart, skeletal muscles, testis, ovary, and pregnant uterus. TMEM97 was originally identified as overexpressed in meningiomas, however, later it was found to exhibit altered expression in different types of cancers. The absence or downregulation of TMEM97 expression in pancreatic cancer suggests that it may acts as a tumor suppressor in pancreatic cancer. Contrastingly, its expression is stronger in breast, esophageal, stomach, colon, and oral squamous cell cancers than the corresponding normal tissues. Its physiological function is largely unknown, however, it has been suggested to implicate in cellular proliferation/differentiation and regulation of cholesterol homeostasis.

Long Name

Sigma intracellular receptor 2

Alternate Names

MAC30, S2R, Sigma-2 receptor, Sigma2 receptor

Gene Symbol

TMEM97

Additional TMEM97 Products

Product Documents for TMEM97 Antibody [DyLight 405]

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for TMEM97 Antibody [DyLight 405]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

TMEM97 Antibody [DyLight 405]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-30436V

Key Product Details

Species Reactivity

Validated:

Predicted:

Applications

Label

Antibody Source

Concentration

View all TMEM97 Antibodies »

Product Summary for TMEM97 Antibody [DyLight 405]

Immunogen

Reactivity Notes

Localization

Clonality

Host

Isotype

Applications for TMEM97 Antibody [DyLight 405]

Immunocytochemistry/ Immunofluorescence

Immunohistochemistry

Immunohistochemistry-Paraffin

Western Blot

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

Concentration

Shipping

Stability & Storage

Background: TMEM97

Long Name

Alternate Names

Gene Symbol

Additional TMEM97 Products

Product Documents for TMEM97 Antibody [DyLight 405]

Product Datasheets

COA

Certificate of Analysis

SDS

Product Specific Notices for TMEM97 Antibody [DyLight 405]