Tollip Antibody (SB40a) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-28621

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # SB40a

Format

Azide and BSA Free

Concentration

0.5 mg/ml

View all Tollip Antibodies »

Product Specifications

Immunogen

Recombinant Tollip

Reactivity Notes

Human

Specificity

Human Tollip; Does not react to TLR2, TLR4, TLR6, TLR7, TLR8 and TLR10 recombinant proteins

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Scientific Data Images for Tollip Antibody (SB40a) - Azide and BSA Free

Western Blot: Tollip Antibody (SB40a)Azide and BSA Free [NBP1-28621]

Western Blot: Tollip Antibody (SB40a)Azide and BSA Free [NBP1-28621]

Western Blot: Tollip Antibody (SB40a) [NBP1-28621] - 2 ug Mouse Anti-Human Tollip-UNLB on Jurkat cell lysate with Goat Anti-Mouse IgG2a, human adsorbed-HRP
Flow Cytometry: Tollip Antibody (SB40a) - Azide and BSA Free [NBP1-28621]

Flow Cytometry: Tollip Antibody (SB40a) - Azide and BSA Free [NBP1-28621]

Flow Cytometry: Tollip Antibody (SB40a) [NBP1-28621] - An intracellular stain was performed on HeLa cells with Tollip Antibody (SB40a) NBP1-28621PE (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 2.5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to phycoerythrin.

Applications for Tollip Antibody (SB40a) - Azide and BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Flow Cytometry

1:10-1:1000

Western Blot

1:100-1:2000

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

0.1M BBS (pH 8.2)

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: Tollip

Tollip, Toll-interacting protein, is a 30 kDa adaptor protein that is a component of the signaling pathway of IL-1 and Toll-like receptors. Tollip forms a complex with IRAK (IL-1 receptor associated kinase) and inhibits IL-1-induced signaling by blocking IRAK phosphorylation. The co-recruitment of MyD88 triggers IRAK autophosphorylation, which in turn leads to the rapid dissociation of IRAK and Tollip. Tollip is also an important signaling component of the TLR2 and TLR4 pathways by playing an inhibitory role in TLRmediated cell activation. Tollip also associates with Tom1 (target of Myb1) forming a complex which regulates endosomal trafficking of ubiquitinated proteins. (1-6)

Long Name

Toll Interacting Protein

Alternate Names

IL-1RAcPIP

Gene Symbol

TOLLIP

Additional Tollip Products

Product Documents for Tollip Antibody (SB40a) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Tollip Antibody (SB40a) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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