TRAIL/TNFSF10 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-2056

Novus Biologicals, part of Bio-Techne
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NB100-2056
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Mouse

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

View all TRAIL/TNFSF10 Antibodies »

Product Specifications

Immunogen

Synthetic peptide (Human) (C terminal).

Localization

Type II membrane protein

Specificity

TRAIL

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TRAIL/TNFSF10 Antibody

Western Blot: TRAIL/TNFSF10 Antibody [NB100-2056]

Western Blot: TRAIL/TNFSF10 Antibody [NB100-2056]

Western Blot: TRAIL/TNFSF10 Antibody [NB100-2056] - Analysis of recombinan human TRAIL at 1.0ug (A) 0.4ug (B) and 0.1ug (C).

Applications for TRAIL/TNFSF10 Antibody

Application
Recommended Usage

Western Blot

1:200
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Constituents: 0.2% Gelatin, PBS

Preservative

0.1% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: TRAIL/TNFSF10

Apoptosis or programmed cell death is induced in cells by a group of death domain containing receptors. Binding of ligand to these receptors sends signals that activate members of the caspase family of proteases. The signals ultimately cause degradation of chromosomal DNA by activating DNase. TRAIL (TNF related apoptosis induced ligand) or Apo 2L initiates apoptosis of tumor cells by binding to either of its receptors, DR4 or DR5. These receptors consist of an extracellular TRAIL binding domain and a cytoplasmic "death domain". In addition, two decoy receptors for TRAIL have also been identified. These receptors, designated DcR1 and DcR2, lack the death domain. Binding of TRAIL to either of these receptors, therefore, does not transmit the death signal. Thus, these receptors represent a novel way of regulating cell sensitivity to a pro-apoptotic cytokine at the cell surface. TRAIL is expressed predominantly in spleen, lung, and prostate but also in many other tissues.

Long Name

TNF-related Apoptosis-inducing Ligand

Alternate Names

CD253, TNFSF10

Entrez Gene IDs

8743 (Human); 22035 (Mouse); 246775 (Rat)

Gene Symbol

TNFSF10

UniProt

P50591

Additional TRAIL/TNFSF10 Products

Product Documents for TRAIL/TNFSF10 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for TRAIL/TNFSF10 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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