VHR/DUSP3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-33099

Novus Biologicals, part of Bio-Techne
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NBP1-33099
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all VHR Antibodies »

Product Summary for VHR/DUSP3 Antibody

Immunogen

Full length human VHR/DUSP3 Recombinant protein.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for VHR/DUSP3 Antibody

Immunohistochemistry-Paraffin: VHR/DUSP3 Antibody [NBP1-33099]

Immunohistochemistry-Paraffin: VHR/DUSP3 Antibody [NBP1-33099]

Immunohistochemistry-Paraffin: VHR/DUSP3 Antibody [NBP1-33099] - Paraffin-embedded N87 xenograft, using antibody at 1:500 dilution.
Western Blot: VHR/DUSP3 Antibody [NBP1-33099]

Western Blot: VHR/DUSP3 Antibody [NBP1-33099]

Western Blot: VHR/DUSP3 Antibody [NBP1-33099] - Sample (50 ug of whole cell lysate) A: mouse stomach 12% SDS PAGE; antibody diluted at 1:1000.
VHR/DUSP3 Antibody

Western Blot: VHR/DUSP3 Antibody [NBP1-33099] -

Western Blot: VHR/DUSP3 Antibody [NBP1-33099] - VHR/DUSP3 antibody detects VHR/DUSP3 protein by western blot analysis. Various whole cell extracts (30 ug) were separated by 15 % SDS-PAGE, and blotted with VHR/DUSP3 antibody (NBP1-33099) diluted by 1:1000

Applications for VHR/DUSP3 Antibody

Application
Recommended Usage

Immunohistochemistry

10 - 1:500

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:500-1:3000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

0.1M Tris (pH 7), 0.1M Glycine, 10% Glycerol

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: VHR

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.

Long Name

Vaccinia Virus VH1-related Phosphatase

Alternate Names

DUSP3

Gene Symbol

DUSP3

Additional VHR Products

Product Documents for VHR/DUSP3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for VHR/DUSP3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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