VE-Cadherin Antibody Pair [HRP]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-79463

Novus Biologicals, part of Bio-Techne
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Key Product Details

Assay Type

Sandwich ELISA

Assay Range

93.75-6000 pg/ml (example only; lot dependent)

Sensitivity

93.75 pg/ml (example only; lot dependent)

Reactivity

Human

View all VE-Cadherin ELISA Kits »

Product Specifications

Description

Solid Phase sandwich ELISA for the quantitative determination of Human VE-Cadherin.

Sample Volume Required

100 ul

Conjugate

HRP

Scientific Data Images for VE-Cadherin Antibody Pair [HRP]

Sandwich ELISA: VE-Cadherin Antibody Pair [HRP] [NBP2-79463]

Kit Contents for VE-Cadherin Antibody Pair [HRP]

  • Mouse Monoclonal Capture Antibody
  • Rabbit Monoclonal Detection Antibody (HRP-conjugated): (Catalog # NBP2-89498)
  • Standard

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Storage of components varies. See protocol for specific instructions.

Background: VE-Cadherin

VE-cadherin (cadherin-5) is an endothelial specific adhesion molecule that is essential for the maintenance of endothelial barrier function and angiogenesis. VE-cadherin is linked to the actin cytoskeleton through a number of adaptor proteins including a-, â-, and ã-catenin. Cytoskeletal dynamics and phosphorylation regulate VE-cadherin mediated cell-cell adhesion. The cytosolic C-terminal Src kinase (Csk) binds via its SH2 domain to the phosphorylated tyrosine 658 site of VE-cadherin. This interaction regulates density dependent cell proliferation. Phosphorylation of tyrosine 658 has also been shown to lead to the uncoupling of p120-catenin from the cytoplasmic tail of VE-cadherin. This phosphorylation event is sufficient to maintain cells in a mesenchymal state during the cell invasion phase of angiogenesis.

Long Name

Vascular Endothelium Cadherin

Alternate Names

Cadherin-5, CD144, CDH5, VECadherin

Gene Symbol

CDH5

Additional VE-Cadherin Products

Product Documents for VE-Cadherin Antibody Pair [HRP]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for VE-Cadherin Antibody Pair [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.

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