Recombinant Mouse IL-3R alpha/CD123 hIgG-His Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-18359

Novus Biologicals, part of Bio-Techne
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Key Product Details

Source

Baculovirus

Tag

hIgG-His

Conjugate

Unconjugated

Applications

SDS-PAGE

View all IL-3R alpha Proteins and Enzymes »

Product Specifications

Description

A recombinant protein of Mouse IL-3R alpha/CD123 with a hIgG-His tag

Source: Baculovirus

Amino Acid Sequence: QIPLCANLVP VPITNATLDR ITGKWFYIAS AFRNEEYNKS VQEIQATFFY FTPNKTEDTI FLREYQTRQD QCIYNTTYLN VQRENGTISR YVGGQEHFAH LLILRDTKTY MLAFDVNDEK NWGLSVYADK PETTKEQLGE FYEALDCLRI PKSDVVYTDW KKDKCEPLEK QHEKERKQEE GES

Purity

>90%, by SDS-PAGE

Endotoxin Level

< 1 EU per 1ug of protein (determined by LAL method)

Predicted Molecular Mass

61.5 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Mouse IL-3R alpha/CD123 hIgG-His Protein

SDS-PAGE: Recombinant Mouse IL-3R alpha/CD123 hIgG-His Protein [NBP3-18359]

SDS-PAGE: Recombinant Mouse IL-3R alpha/CD123 hIgG-His Protein [NBP3-18359]

SDS-Page: Recombinant Mouse IL-3R alpha/CD123 hIgG-His Protein [NBP3-18359] - 3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain

Formulation, Preparation and Storage

NBP3-18359
Formulation 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 30% glycerol
Preservative No Preservative
Concentration 0.25 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IL-3R alpha

IL3RA (CD123) is a member of the immunoglobulin superfamily that is expressed on hematopoietic progenitors, basophils, mast cells, and megakaryocytes. This transmembrane glycoprotein can bind IL3 with low affinity but cannot transduce signals without association with additional protein partners. CD123 can complex with either common beta chain (CDw131) or the IL3RB chain to form high affinity heterodimeric IL3 receptors. CDw131 can complex with the Alpha subunits of the mouse IL3R, IL5R and GMCSFR to form high affinity receptors, while the IL3RB subunit is specific for IL3 but binds with low affinity. IL3 binding to the receptor complex can induce proliferation and differentiation of hematopoietic cells. It is present in Hematopoietic progenitors, basophils, mast cells and megakaryocytes.

Long Name

Interleukin 3 Receptor alpha

Alternate Names

CD123, IL-3 R alpha, IL-3Ra, IL3R alpha, IL3RA

Gene Symbol

IL3RA

Additional IL-3R alpha Products

Product Documents for Recombinant Mouse IL-3R alpha/CD123 hIgG-His Protein

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Mouse IL-3R alpha/CD123 hIgG-His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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