MAP3K8/Tpl2/COT Antibody Blocking Peptide

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-62178PEP

Novus Biologicals, part of Bio-Techne
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NBP1-62178PEP
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Key Product Details

Conjugate

Unconjugated

Applications

Antibody Competition

View all MAP3K8/Tpl2/COT Proteins and Enzymes »

Product Specifications

Description

A MAP3K8/Tpl2/COT antibody blocking peptide.

Purity

>85%, by HPLC

Application Notes

This peptide is useful as a blocking peptide for NBP1-62178. For further blocking peptide related protocol, click here.

Protein / Peptide Type

Antibody Blocking Peptide

Formulation, Preparation and Storage

NBP1-62178PEP
Formulation Sodium Bicarbonate buffer, pH 8.00 containing up to 10% DMSO
Concentration 2.5 mg/ml
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -20C. Avoid freeze-thaw cycles.

Background: MAP3K8/Tpl2/COT

Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant.

Long Name

Mitogen-activated Protein Kinase Kinase Kinase 8

Alternate Names

COT, EST, ESTF, MAP3K8, Tpl-2

Gene Symbol

MAP3K8

Additional MAP3K8/Tpl2/COT Products

Product Documents for MAP3K8/Tpl2/COT Antibody Blocking Peptide

Product Datasheets

Certificate of Analysis

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Product Specific Notices for MAP3K8/Tpl2/COT Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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