MAP3K8/Tpl2/COT Products
MAP3K8, also called Tpl2 (tumor progression locus 2) or COT (Cancer Osaka Thyroid oncogene), is a cytosolic Ser/Thr kinase. MAP3K8 is one of the MAP kinase kinase (MAPKK) kinases that regulates the ERK1/ERK2 pathway in response to IL-1, facilitating IL-8 and MIP-1 beta production. MAP3K8 activates I kappa B kinases and induces the nuclear production of NF-kappa B.
35 results for "MAP3K8/Tpl2/COT" in Products
35 results for "MAP3K8/Tpl2/COT" in Products
MAP3K8/Tpl2/COT Products
MAP3K8, also called Tpl2 (tumor progression locus 2) or COT (Cancer Osaka Thyroid oncogene), is a cytosolic Ser/Thr kinase. MAP3K8 is one of the MAP kinase kinase (MAPKK) kinases that regulates the ERK1/ERK2 pathway in response to IL-1, facilitating IL-8 and MIP-1 beta production. MAP3K8 activates I kappa B kinases and induces the nuclear production of NF-kappa B.
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #634130 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, IP |
![Western Blot: MAP3K8/Tpl2/COT Antibody [NBP1-62178]](https://resources.bio-techne.com/images/products/MAP3K8-Tpl2-COT-Antibody-Western-Blot-NBP1-62178-img0001.jpg "Western Blot: MAP3K8/Tpl2/COT Antibody [NBP1-62178]")
| Source: | Sf 9 (baculovirus) |
| Accession #: | NM_005204 |
| Applications: | BA |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #HL2118 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: MAP3K8/Tpl2/COT Antibody [NBP1-86569]](https://resources.bio-techne.com/images/products/MAP3K8-Tpl2-COT-Antibody-Western-Blot-NBP1-86569-img0011.jpg "Western Blot: MAP3K8/Tpl2/COT Antibody [NBP1-86569]")
| Applications: | WB |
![Western Blot: MAP3K8/Tpl2/COT Overexpression Lysate [NBL1-12859]](https://resources.bio-techne.com/images/products/MAP3K8-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-12859-img0002.jpg "Western Blot: MAP3K8/Tpl2/COT Overexpression Lysate [NBL1-12859]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI3D9 |
| Applications: | WB |
![Western Blot: MAP3K8/Tpl2/COT Antibody (OTI3D9) [NBP2-45741]](https://resources.bio-techne.com/images/products/MAP3K8-Tpl2-COT-Antibody-3D9-Western-Blot-NBP2-45741-img0001.jpg "Western Blot: MAP3K8/Tpl2/COT Antibody (OTI3D9) [NBP2-45741]")
| Reactivity: | Human |
| Details: | Rabbit Polyclonal |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: MAP3K8/Tpl2/COT Antibody [NBP3-14395]](https://resources.bio-techne.com/images/products/MAP3K8-Tpl2-COT "Immunohistochemistry-Paraffin: MAP3K8/Tpl2/COT Antibody [NBP3-14395]")
| Applications: | AC |
| Applications: | AC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI3D9 |
| Applications: | WB |
Potent and selective Tpl2 (Cot; MAP3K8) inhibitor
| Chemical Name: | 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile |
| Purity: | ≥99% (HPLC) |
Potent and selective Tpl2 (MAP3K8) inhibitor
| Chemical Name: | 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-quinolinecarbonitrile |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI3D9 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI3D9 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI3D9 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI3D9 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI3D9 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI3D9 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI3D9 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI3D9 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI3D9 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI3D9 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI3D9 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI3D9 |
| Applications: | WB |