CCG 1423

Name: CCG 1423
Brand: Tocris Bioscience
SKU: 5233

Tocris Bioscience, part of Bio-Techne | Catalog # 5233

Citations (14)

COA / SDS

Rho/SRF pathway inhibitor; induces intermediate mesoderm differentiation from ESCs

Discontinued Product

5233 has been discontinued. View all Rho GTPase Inhibitors products.

Key Product Details

Description:	Rho/SRF pathway inhibitor; induces intermediate mesoderm differentiation from ESCs
Chemical Name:	N-[2-[(4-Chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)benzamide
Purity:	≥99% (HPLC)
Molecular Weight:	454.75

View Full Technical Details for CCG 1423

Technical Data
Citations

Biological Activity for CCG 1423

CCG 1423 is a Rho/SRF pathway inhibitor; stimulates apoptosis of a melanoma cell line overexpressing RhoC (A375M2). Suppresses Rho-dependent invasion of PC-3 prostate cancer cells in vitro and inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells. When used in combination with Retinoic acid, LY 294002 and Pyridone 6, it induces intermediate mesoderm differentiation from ESCs.

Compound Libraries for CCG 1423

CCG 1423 is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for CCG 1423

M. Wt	454.75
Formula	C₁₈H₁₃ClF₆N₂O₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	285986-88-1
PubChem ID	2726015
InChi Key	DSMXVSGJIDFLKP-UHFFFAOYSA-N
Smiles	O=C(NOC(C)C(NC2=CC=C(Cl)C=C2)=O)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for CCG 1423

References are publications that support the biological activity of the product.

Evelyn CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. Mol.Cancer Ther. 2007 PMID: 17699722
Mae Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. Biochem.Biophys.Res.Commun. 2010 PMID: 20171952