ML 120B dihydrochloride

Name: ML 120B dihydrochloride
Brand: Tocris Bioscience
SKU: 4899

Tocris Bioscience, part of Bio-Techne | Catalog # 4899

(1)

Citations (1)

COA / SDS

Novel IKK2-selective inhibitor

Key Product Details

Chemical Name:	N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride
Purity:	≥98%

View Full Technical Details for ML 120B dihydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for ML 120B dihydrochloride

ML 120B dihydrochloride is a novel, ATP-competitive IKK2-selective inhibitor (IC₅₀ = 60 nM at 50 μM ATP). Exhibits no inhibition at IKK1 (EC₅₀ >100 μM), IKKε (EC₅₀ >100 μM) or a panel of 28 other kinases (EC₅₀ >50 μM). Exhibits antitumor activity in lymphoma-bearing SCID mice. Demonstrates synergistic cytotoxic effects with vincristine (Cat. No. 1257).

Technical Data for ML 120B dihydrochloride

Formula	C₁₉H₁₅ClN₄O₂.2HCl
Storage	Store at -20°C
Purity	≥98%
CAS Number	1782573-78-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 120B dihydrochloride

Solubility

Soluble Soluble to 20 mM in DMSO and to 5 mM in water with gentle warming

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References for ML 120B dihydrochloride

References are publications that support the biological activity of the product.

Catley et al. Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle. Mol.Pharmacol., 2006;70:697 PMID: 16687566
Nagashima et al. Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKbeta. Blood, 2006;107:4266 PMID: 16439676
Al-Katib et al. I-kappa-kinase-2 (IKK-2) inhibition potentiates vincri. cytotoxicity in non-Hodgkin's lymphoma. Mol.Cancer, 2010;9:1476 PMID: 20809973

ML 120B dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4899

Key Product Details

Biological Activity for ML 120B dihydrochloride

Technical Data for ML 120B dihydrochloride

Solubility for ML 120B dihydrochloride

Dilution Calculator

Reconstitution Calculator

References for ML 120B dihydrochloride

Product Documents for ML 120B dihydrochloride

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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