Palonosetron hydrochloride

Name: Palonosetron hydrochloride
Brand: Tocris Bioscience
SKU: 7038

Tocris Bioscience, part of Bio-Techne | Catalog # 7038

Citations (2)

COA / SDS

Highly potent and high affinity 5-HT3 antagonist

Key Product Details

Description:	Highly potent and high affinity 5-HT₃ antagonist
Chemical Name:	(3aS)-2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	332.87

View Full Technical Details for Palonosetron hydrochloride

Technical Data
Citations

Biological Activity for Palonosetron hydrochloride

Palonosetron hydrochloride is a highly potent and high affinity 5-HT₃ antagonist (IC₅₀ = 0.24 nM for 5-HT_3A; pK_i = 10.4). Displays a slow dissociation rate. Inhibits 5-HT-induced enhancement of cellular response to substance P (Cat. No. 1156) in vitro. Inhibits cisplatin (Cat. No. 2251)-induced enhancement of substance P response in vivo.

Technical Data for Palonosetron hydrochloride

M. Wt	332.87
Formula	C₁₉H₂₄N₂O.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	135729-62-3
PubChem ID	6918303
InChi Key	OLDRWYVIKMSFFB-SSPJITILSA-N
Smiles	O=C1N([C@@H]2CN3CCC2CC3)C[C@@]4([H])CCCC5=C4C1=CC=C5.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Palonosetron hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	33.29	100
	DMSO	3.33	10

Preparing Stock Solutions for Palonosetron hydrochloride

The following data is based on the product molecular weight 332.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.00 mL	15.02 mL	30.04 mL
5 mM	0.60 mL	3.00 mL	6.01 mL
10 mM	0.30 mL	1.50 mL	3.00 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for Palonosetron hydrochloride

References are publications that support the biological activity of the product.

Del Cadia Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor. Bioorg.Med.Chem. 2013 PMID: 24128813
Rojas The antiemetic 5-HT₃ receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo. J.Pharmacol.Exp.Ther. 2010 PMID: 20724484
Lummis & Thompson Agonists and antagonists induce different palonosetron dissociation rates in 5-HT_3A and 5-HT_3AB receptors. Neuropharmacology. 2013 PMID: 23747573
Wong The interaction of RS 25259-197, a potent and selective antagonist, with 5-HT₃ receptors, in vitro. Br.J.Pharmacol. 1995 PMID: 7773546