Thalidomide, 5'-fluoro

Name: Thalidomide, 5'-fluoro
Brand: Tocris Bioscience
SKU: 7456

Tocris Bioscience, part of Bio-Techne | Catalog # 7456

COA / SDS

Fluoro functionalized Thalidomide; cereblon ligand for PROTACs

Key Product Details

Description:	Fluoro functionalized Thalidomide; cereblon ligand for PROTACs
Chemical Name:	2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-1H-isoindole-1,3(2H)-dione
Purity:	≥95%
Molecular Weight:	276.22

View Full Technical Details for Thalidomide, 5'-fluoro

Technical Data
Citations

Biological Activity for Thalidomide, 5'-fluoro

Thalidomide 5'- fluoro is a derivative of Thalidomide (Cat. No. 0652), commonly used as a precursor to PROTAC^® Degraders that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with a fluoro functional handle at a position known not to significantly affect binding to cereblon, ready for conjugation to a linker/target protein ligand.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Require a different derivative? Get in touch.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for Thalidomide, 5'-fluoro

M. Wt	276.22
Formula	C₁₃H₉FN₂O₄
Storage	Store at +4°C
Purity	≥95%
CAS Number	835616-61-0
PubChem ID	70876201
InChi Key	MPQLCQKBYRSPNA-UHFFFAOYSA-N
Smiles	FC1=CC=C2C(N(C(C2=C1)=O)C3CCC(NC3=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Thalidomide, 5'-fluoro

References are publications that support the biological activity of the product.

Burslem Efficient synthesis of immunomodulatory drug analogues enables exploration of structure-degradation relationships. Chem.Med.Chem. 2018 PMID: 29870139