B7-H2 Products
Human B7-H2, also called B7RP-1, B7h, LICOS, and GL50, is a member of the growing B7 family of immune costimulatory proteins. Other family members include B7-1, B7-2, B7-H1 (PD-L1), PD-L2, and B7-H3. B7 proteins are members of the immunoglobulin (Ig) superfamily, the extracellular domains contain 2 Ig-like domains and all members have short cytoplasmic domains. Among the family members, they share about 20-25% amino acid identity. Human and mouse B7-H2 share approximately 49% amino acid identity.
B7-H2 has been identified as the ligand for ICOS, a member of the CD28 family of costimulatory receptors. Human B7-H2 is a 309 amino acid (aa) protein with a putative 18 aa signal peptide, a 239 aa extracellular domain, an 18 aa transmembrane region, and a 33 aa cytoplasmic domain. Human B7-H2 is expressed constitutively on resting B cells, dendritic cells, and at low levels on monocytes. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and T Helper (Th) cell differentiation.
Products:
329 results for "B7-H2" in Products
329 results for "B7-H2" in Products
B7-H2 Products
Human B7-H2, also called B7RP-1, B7h, LICOS, and GL50, is a member of the growing B7 family of immune costimulatory proteins. Other family members include B7-1, B7-2, B7-H1 (PD-L1), PD-L2, and B7-H3. B7 proteins are members of the immunoglobulin (Ig) superfamily, the extracellular domains contain 2 Ig-like domains and all members have short cytoplasmic domains. Among the family members, they share about 20-25% amino acid identity. Human and mouse B7-H2 share approximately 49% amino acid identity.
B7-H2 has been identified as the ligand for ICOS, a member of the CD28 family of costimulatory receptors. Human B7-H2 is a 309 amino acid (aa) protein with a putative 18 aa signal peptide, a 239 aa extracellular domain, an 18 aa transmembrane region, and a 33 aa cytoplasmic domain. Human B7-H2 is expressed constitutively on resting B cells, dendritic cells, and at low levels on monocytes. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and T Helper (Th) cell differentiation.
Products:
Source: | NS0 |
Accession #: | Q9JHJ8 |
Applications: | BA |
Reactivity: | Mouse |
Details: | Rat IgG1 Monoclonal Clone #599841 |
Applications: | Flow, CyTOF-ready, ICC |
Reactivity: | Human |
Details: | Mouse IgG2b Monoclonal Clone #136726 |
Applications: | Flow, CyTOF-ready, Neut |
Reactivity: | Human |
Details: | Goat IgG Polyclonal |
Applications: | WB, Flow, CyTOF-ready |
Source: | NS0 |
Accession #: | O75144.2 |
Applications: | BA |
Reactivity: | Human |
Details: | Mouse IgG2b Monoclonal Clone #136726 |
Applications: | Flow |
Reactivity: | Mouse |
Details: | Rat IgG2a Monoclonal Clone #987602 |
Applications: | Flow, Block, CyTOF-ready, Neut |
Source: | NS0 |
Accession #: | Q9JHJ8 |
Applications: | Bind |
Reactivity: | Human |
Details: | Mouse IgG2b Monoclonal Clone #136726 |
Applications: | Flow |
Assay Range: | 31.2 - 2,000 pg/mL |
Applications: | ELISA |
Biotinylated
Source: | CHO |
Accession #: | O75144.1 |
Applications: | BA, BA |
Source: | HEK293 |
Accession #: | O75144 |
Applications: | BA, BA |
Reactivity: | Human |
Details: | Mouse IgG2b Monoclonal Clone #136726 |
Applications: | Flow |
Reactivity: | Human |
Details: | Mouse IgG2b Monoclonal Clone #136726 |
Applications: | Flow |
Source: | NS0 |
Accession #: | XP_006256322.1 |
Applications: | BA |
Reactivity: | Human |
Details: | Mouse IgG2b Monoclonal Clone #136726 |
Applications: | Flow |
Reactivity: | Mouse |
Details: | Goat IgG Polyclonal |
Applications: | WB, ICC |
Reactivity: | Mouse |
Details: | Rat IgG1 Monoclonal Clone #987614 |
Applications: | Flow, Block, CyTOF-ready |
Assay Range: | 39.1 - 2,500 pg/mL |
Applications: | ELISA |
Reactivity: | Mouse |
Details: | Rat IgG1 Monoclonal Clone #599841 |
Applications: | Flow |
Reactivity: | Mouse |
Details: | Rat IgG2a Monoclonal Clone #987602 |
Applications: | Flow |
Reactivity: | Human |
Details: | Goat IgG Polyclonal |
Applications: | WB, Flow |