cIAP (pan) Products
Cellular inhibitor of apoptosis protein1 (cIAP-1, also known as BIRC2, MIHB, and HIAP2) and 2 (cIAP-2, also known as BIRC3, MIHC, and HIAP1), are members of the inhibitor of apoptosis (IAP) family of proteins that inhibit the proteolytic activity of mature caspases. Structurally, cIAP-1 and cIAP-2 are each comprised of 3 BIR (baculovirus inhibitor of apoptosis) domains, a RING finger domain, and a caspase recruitment domain (CARD). Human cIAP-1 and cIAP-2 share 70% sequence identity. Functionally, cIAPs inhibit caspases through the direct interaction of its BIR domain with the active caspase. The ring finger domain of cIAP-1 and cIAP-2 also functions as an E3 ubiquitin ligase to ubiqutinylate specific target proteins. Caspase activity may be restored by mitochondrial proteins, such as SMAC/Diablo or HtrA2/Omi, through interactions with the Reaper-like motif and the BIR domain. cIAPs are reported to be cleaved by HtrA2/Omi.
9 results for "cIAP (pan)" in Products
9 results for "cIAP (pan)" in Products
cIAP (pan) Products
Cellular inhibitor of apoptosis protein1 (cIAP-1, also known as BIRC2, MIHB, and HIAP2) and 2 (cIAP-2, also known as BIRC3, MIHC, and HIAP1), are members of the inhibitor of apoptosis (IAP) family of proteins that inhibit the proteolytic activity of mature caspases. Structurally, cIAP-1 and cIAP-2 are each comprised of 3 BIR (baculovirus inhibitor of apoptosis) domains, a RING finger domain, and a caspase recruitment domain (CARD). Human cIAP-1 and cIAP-2 share 70% sequence identity. Functionally, cIAPs inhibit caspases through the direct interaction of its BIR domain with the active caspase. The ring finger domain of cIAP-1 and cIAP-2 also functions as an E3 ubiquitin ligase to ubiqutinylate specific target proteins. Caspase activity may be restored by mitochondrial proteins, such as SMAC/Diablo or HtrA2/Omi, through interactions with the Reaper-like motif and the BIR domain. cIAPs are reported to be cleaved by HtrA2/Omi.
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2a Monoclonal Clone #315301 |
| Applications: | WB, Simple Western |
| Source: | Sf 21 (baculovirus) |
| Accession #: | O95407 |
| Applications: | BA |
Dimeric Smac mimetic; potent IAP inhibitor
| Chemical Name: | 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide |
| Purity: | ≥97% (HPLC) |
Functionalized IAP ligand for PROTACs
| Chemical Name: | tert-Butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(4-(3-hydroxybenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate |
| Purity: | ≥95% (HPLC) |
IAP ligand with PEG linker and terminal amine for onward chemistry
| Chemical Name: | tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-[2-[2-2-[(2-aminoethoxy)ethoxy]ethoxy]acetamido]-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate |
| Purity: | ≥95% (HPLC) |
IAP ligand with PEG linker and terminal amine for onward chemistry
| Chemical Name: | tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-[2-[2-(2-aminoethoxy)ethoxy]acetamido]-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate |
| Purity: | ≥95% (HPLC) |
IAP ligand with PEG linker and terminal amine for onward chemistry
| Chemical Name: | tert-Butyl ((S)-1-(((S)-2-((2S,4S)-4-(14-amino-3,6,9,12-tetraoxatetradecanamido)-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate |
| Purity: | ≥95% (HPLC) |
IAP ligand with PEG linker and terminal amine for onward chemistry
| Chemical Name: | tert-Butyl ((S)-1-(((S)-2-((2S,4S)-4-(17-amino-3,6,9,12,15-pentaoxaheptadecanamido)-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate |
| Purity: | ≥95% (HPLC) |
IAP ligand with alkyl linker and terminal amine for onward chemistry
| Chemical Name: | tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-(5-Aminopentanamido)-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate |
| Purity: | ≥95% (HPLC) |
