FGFR3: Proteins and Enzymes
FGFR3 (fibroblast growth factor receptor 3), also known as CEK2 and CD333, is a transmembrane receptor tyrosine kinase that plays a role in skeletal development and tumorigenesis. Alternative splicing generates beta isoforms of the receptor which lack the first Ig-like domain as well as IIIb isoforms that have a substitution in the third Ig-like domain.
FGFR3 (IIIb) triggers cell proliferation in response to FGF acidic and FGF-9 while FGFR3 (IIIc) shows a wider selectivity that includes FGF acidic, FGF basic/FGF2, FGF-4, -8, -9, -17, -18, -19, and -20. FGF-mediated activation of FGFR3 is dependent on the presence of heparan sulfate proteoglycans. FGFR3 functions as a negative regulator of endochondral bone growth, and FGFR3 mutations are associated with chondrodysplasia in humans. The development of many cancers is associated with mutations or dysregulation of FGFR3.
Products:
7 results for "FGFR3 Proteins and Enzymes" in Products
7 results for "FGFR3 Proteins and Enzymes" in Products
FGFR3: Proteins and Enzymes
FGFR3 (fibroblast growth factor receptor 3), also known as CEK2 and CD333, is a transmembrane receptor tyrosine kinase that plays a role in skeletal development and tumorigenesis. Alternative splicing generates beta isoforms of the receptor which lack the first Ig-like domain as well as IIIb isoforms that have a substitution in the third Ig-like domain.
FGFR3 (IIIb) triggers cell proliferation in response to FGF acidic and FGF-9 while FGFR3 (IIIc) shows a wider selectivity that includes FGF acidic, FGF basic/FGF2, FGF-4, -8, -9, -17, -18, -19, and -20. FGF-mediated activation of FGFR3 is dependent on the presence of heparan sulfate proteoglycans. FGFR3 functions as a negative regulator of endochondral bone growth, and FGFR3 mutations are associated with chondrodysplasia in humans. The development of many cancers is associated with mutations or dysregulation of FGFR3.
Products:
Biotinylated
| Source: | HEK293 |
| Accession #: | NP_001156685.1 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | P22607 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | Q61851 |
| Applications: | BA |
Biotinylated
| Source: | HEK293 |
| Accession #: | NP_001156685.1 |
| Applications: | BA |
Biotinylated Fc Chimera
| Source: | HEK293 |
| Accession #: | P22607.1 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | NP_001156689 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | NP_001156685 |
| Applications: | BA |