IGFBP-3 Products
IGFBP-3 (Insulin-like growth factor binding protein-3) modulates the biological activity of IGF. It circulates in a ternary complex with IGF and the acid-labile subunit (ALS). Proteolysis of IGFBP-3 by tissue plasminogen activator (tPA), a disintegrin and metalloproteases (ADAMs), and prostate specific antigen (PSA) contributes to IGFBP-3 degradation or a reduction in its affinity for IGF. The majority of soluble IGFBP-3 found in circulation is secreted from hepatic non-parenchymal cells. IGFBP-3 potentiates EGF-EGFR-mediated cell growth, modulates adipogenesis, and regulates TGF-beta signaling, DNA damage, apoptosis, autophagy, and gene transcription.
179 results for "IGFBP-3" in Products
179 results for "IGFBP-3" in Products
IGFBP-3 Products
IGFBP-3 (Insulin-like growth factor binding protein-3) modulates the biological activity of IGF. It circulates in a ternary complex with IGF and the acid-labile subunit (ALS). Proteolysis of IGFBP-3 by tissue plasminogen activator (tPA), a disintegrin and metalloproteases (ADAMs), and prostate specific antigen (PSA) contributes to IGFBP-3 degradation or a reduction in its affinity for IGF. The majority of soluble IGFBP-3 found in circulation is secreted from hepatic non-parenchymal cells. IGFBP-3 potentiates EGF-EGFR-mediated cell growth, modulates adipogenesis, and regulates TGF-beta signaling, DNA damage, apoptosis, autophagy, and gene transcription.
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #IGFBP3/3423 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #IGFBP3/3423 |
| Applications: | IHC |
Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies
Contains 4 membranes - each spotted in duplicate with 55 different angiogenesis antibodies
Contains 4 membranes-each spotted in duplicate with 111 different cytokine antibodies
| Sensitivity: | 0.14 ng/mL |
| Applications: | ELISA |
| Assay Range: | 0.781 - 50 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma) |
| Sensitivity: | 16 pg/mL |
| Applications: | ELISA |
| Assay Range: | 78.1 - 5,000 pg/mL (Cell Culture Supernates, EDTA Plasma) |
High affinity insulin-like growth factor-I binding protein IGFBP inhibitor
| Chemical Name: | 1-(3,4-Dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid |
| Purity: | ≥98% (HPLC) |
| Source: | NS0 |
| Accession #: | CAA46087 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #84728 |
| Applications: | WB, IHC |
Contains 4 membranes-each spotted in duplicate with 79 different cytokine antibodies
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Neut |
Sf 9 (baculovirus)-expressed
| Source: | Sf 9 (baculovirus) |
| Accession #: | P17936 |
| Applications: | BA |
| Assay Range: | 125 - 8,000 pg/mL |
| Applications: | ELISA |
Contains 4 membranes - each spotted in duplicate with 53 different angiogenesis antibodies
Contains 4 membranes - each spotted in duplicate with 38 different obesity-related antibodies
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #138202 |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western |
Contains 4 membranes-each spotted in duplicate with 58 different obesity-related antibodies
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Immunohistochemistry-Frozen: IGFBP-3 Antibody [NBP2-16933]](https://resources.bio-techne.com/images/products/IGFBP-3-Antibody-Immunohistochemistry-Frozen-NBP2-16933-img0002.jpg "Immunohistochemistry-Frozen: IGFBP-3 Antibody [NBP2-16933]")
| Source: | NS0 |
| Accession #: | CAA57271.1 |
| Applications: | BA |
| Assay Range: | 62.5 - 4,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
Contains 4 membranes - each spotted in duplicate with 30 different obesity-related antibodies