IL-12 Products
IL-12 (Interleukin-12) is a heterodimeric cytokine that consists of a p35 and a p40 subunit. p40 is also a subunit of the cytokine IL-23. IL-12 enhances the cytotoxic activity and induces IFN-gamma production in NK cells, T cells, and dendritic epidermal T cells, and it promotes a Th1 biased immune response. It signals through a receptor complex composed of IL-12 R beta 1 and IL-12 R beta 2. Both homodimeric p40, and IL-23 can bind to the IL-12 receptor, serving as non-signaling antagonists.
127 results for "IL-12" in Products
127 results for "IL-12" in Products
IL-12 Products
IL-12 (Interleukin-12) is a heterodimeric cytokine that consists of a p35 and a p40 subunit. p40 is also a subunit of the cytokine IL-23. IL-12 enhances the cytotoxic activity and induces IFN-gamma production in NK cells, T cells, and dendritic epidermal T cells, and it promotes a Th1 biased immune response. It signals through a receptor complex composed of IL-12 R beta 1 and IL-12 R beta 2. Both homodimeric p40, and IL-23 can bind to the IL-12 receptor, serving as non-signaling antagonists.
| Sensitivity: | 2.5 pg/mL |
| Applications: | ELISA |
| Assay Range: | 7.8 - 500 pg/mL (Cell Culture Supernates, Serum) |
GS Linker, Defined heterodimer stoichiometry.
| Source: | HEK293 |
| Accession #: | P29460.1 (IL-12p40), P29459.2 (IL-12p35) |
| Applications: | BA |
| Assay Range: | 39.1 - 2,500 pg/mL |
| Applications: | ELISA |
| Assay Range: | 31.2 - 2,000 pg/mL |
| Applications: | ELISA |
| Source: | Sf 21 (baculovirus) |
| Accession #: | NP_072133 (p40) & Q9R103 (p35) |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #24910 |
| Applications: | WB, IHC, Neut |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 Monoclonal Clone #27537 |
| Applications: | WB, CyTOF-ready, ICFlow |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC, Neut |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 Monoclonal Clone #27537 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC |
| Source: | Sf 21 (baculovirus) |
| Accession #: | P43432 (p40) & NP_032377 (p35) |
| Applications: | BA |
| Reactivity: | Mouse |
| Details: | Rat IgG1 Monoclonal Clone #48110 |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
GS Linker, Defined heterodimer stoichiometry.
| Source: | HEK293 |
| Accession #: | NP_001274204 (IL-12p40) & XP_005546300 (IL-12p35) |
| Applications: | BA |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Neut |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Neut |
| Source: | CHO |
| Accession #: | Q28268 (p40) & Q28267 (p35) |
| Applications: | BA |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 Monoclonal Clone #27537 |
| Applications: | ICFlow |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #24945R |
| Applications: | ICC |
| Source: | Sf 21 (baculovirus) |
| Accession #: | O02744 (p40) & O02743 (p35) |
| Applications: | BA |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2038C |
| Applications: | ICC, ICFlow |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Neut |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #45806 |
| Applications: | IHC |
| Source: | CHO |
| Accession #: | Q28938 (p40) & Q29053 (p35) |
| Applications: | BA |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 Monoclonal Clone #27537 |
| Applications: | ICFlow |
