Spike Products
The Coronavirus Spike protein (S Protein) is one of four major structural proteins (S, M, E, N) present in each viral particle. Spike proteins are abundantly expressed on the surface forming its characteristic crown-like halo structure. The Spike protein is a highly glycosylated, type I transmembrane protein that plays a critical role in receptor recognition and host cell entry. There are two subunits, S1 and S2, that divide the protein roughly in half.
Within the N-terminal S1 subunit is the N-terminal domain and receptor binding domain (Spike RBD protein). The Spike RBD binds to the host cell and undergoes several conformational changes and proteolysis leading to fusion of the virus particle to the host cell membrane allowing transfer of the nucleocapsid into the host cell cytoplasm. For SARS-CoV-2, the virus responsible for the COVID-19 pandemic, the Spike RBD tightly associates with human ACE-2. Recombinant SARS-CoV-2 proteins and antibodies that recognize these proteins are essential for studying the molecular mechanisms of the coronavirus life cycle.
Products:
502 results for "Spike" in Products
502 results for "Spike" in Products
Spike Products
The Coronavirus Spike protein (S Protein) is one of four major structural proteins (S, M, E, N) present in each viral particle. Spike proteins are abundantly expressed on the surface forming its characteristic crown-like halo structure. The Spike protein is a highly glycosylated, type I transmembrane protein that plays a critical role in receptor recognition and host cell entry. There are two subunits, S1 and S2, that divide the protein roughly in half.
Within the N-terminal S1 subunit is the N-terminal domain and receptor binding domain (Spike RBD protein). The Spike RBD binds to the host cell and undergoes several conformational changes and proteolysis leading to fusion of the virus particle to the host cell membrane allowing transfer of the nucleocapsid into the host cell cytoplasm. For SARS-CoV-2, the virus responsible for the COVID-19 pandemic, the Spike RBD tightly associates with human ACE-2. Recombinant SARS-CoV-2 proteins and antibodies that recognize these proteins are essential for studying the molecular mechanisms of the coronavirus life cycle.
Products:
Ectodomain, Stabilized Prefusion Conformation, Resistant to Furin Cleavage
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
(1-1273 4x aa mut.)
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
Omicron variant
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
Beta Variant (South Africa)
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
L452R T478K Delta Variant (India)
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
Omnicron Variant
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
Delta Variant (India) His-tag
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
His-tag Biotinylated Gamma Variant (Brazil)
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
Recombinant Monoclonal Antibody
| Reactivity: | SARS-CoV-2, SARS-CoV, Virus - SARS-CoV-2 |
| Details: | Human IgG1 kappa Monoclonal Clone #CR3022 |
| Applications: | ELISA, ICC/IF, MA, B/N, SPR |
![ELISA: SARS-CoV-2 Spike Antibody (CR3022) - Azide and BSA Free [NBP2-90980]](https://resources.bio-techne.com/images/products/SARS-CoV-2-Spike-Antibody-CR3022-ELISA-NBP2-90980-img0001.jpg "ELISA: SARS-CoV-2 Spike Antibody (CR3022) - Azide and BSA Free [NBP2-90980]")
Biotinylated
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
Biotinylated via Amines
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
Alpha Variant (UK) with S494P Mutation. His-tag
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
5 Point Mutations (D614G, R682S, R685S, K986P, V987P)
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
Alpha Variant (UK) Resistant to Furin & Stabilized Prefusion Conformation
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
His-tag
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
(GCN4-IZ) His-tag Gamma (Brazilian) Variant
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
| Applications: | ELISA |
![ELISA: SARS-CoV-2 Spike Recombinant Protein [NBP3-14666]](https://resources.bio-techne.com/images/products/SARS-CoV-2-Spike-Recombinant-Protein-ELISA-NBP3-14666-img0001.jpg "ELISA: SARS-CoV-2 Spike Recombinant Protein [NBP3-14666]")
| Source: | CHO |
| Accession #: | YP_009724390.1 |
| Applications: | BA, BA |
| Source: | HEK293 |
| Accession #: | P59594.1 |
| Applications: | BA |
Alpha Variant (UK)
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
Omicron Variant His-tag
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
GCN4-IZ trimerization domain, Stabilized Prefusion Conformation, Resistant to Furin Cleavage
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
| Reactivity: | SARS-CoV-2 |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF |
![ELISA: SARS-CoV-2 Spike Antibody - BSA Free [NBP3-11940]](https://resources.bio-techne.com/images/products/SARS-CoV-2-Spike-Antibody-ELISA-NBP3-11940-img0009.jpg "ELISA: SARS-CoV-2 Spike Antibody - BSA Free [NBP3-11940]")
Y144 del, A222V, Delta Variant (Vietnam) His-tag
| Source: | HEK293 |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
GCN4-IZ trimerization domain, Stabilized Prefusion Conformation, Resistant to Furin Cleavage
| Source: | CHO |
| Accession #: | YP_009724390.1 |
| Applications: | BA |
