Skip to main content

STAT3 Products

The STAT family of transcription factors, first described as key mediators of interferon signal transduction, are now recognized as signaling factors downstream of many cytokines, growth factors, and hormones. At least seven STATs exist: STAT1, 2, 3, 4, 5a, 5b, and 6. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. They are characterized structurally by the presence of the Src homology 2 (SH2) domain, and a C-terminal tyrosine phosphorylation site. Upon ligand binding, they are recruited to the activated receptor, via their SH2 domains, to receptor-associated tyrosine kinases of the Janus kinase family (JAK). Once phosphorylated by JAK, STATS are free to hetero- or homo-dimerize, and translocate to the nucleus where they bind DNA to regulate gene transcription.

Show More

195 results for "STAT3" in Products

Back to Search Results
应用

195 results for "STAT3" in Products

STAT3 Products

The STAT family of transcription factors, first described as key mediators of interferon signal transduction, are now recognized as signaling factors downstream of many cytokines, growth factors, and hormones. At least seven STATs exist: STAT1, 2, 3, 4, 5a, 5b, and 6. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. They are characterized structurally by the presence of the Src homology 2 (SH2) domain, and a C-terminal tyrosine phosphorylation site. Upon ligand binding, they are recruited to the activated receptor, via their SH2 domains, to receptor-associated tyrosine kinases of the Janus kinase family (JAK). Once phosphorylated by JAK, STATS are free to hetero- or homo-dimerize, and translocate to the nucleus where they bind DNA to regulate gene transcription.

Show More
Applications: WB, IP, ICC, ICFlow, KO
Reactivity: Human, Mouse, Rat
Applications: WB, Simple Western, Flow, CyTOF-ready, ICC
Reactivity: Human
Applications: WB, ICFlow
Reactivity: Human
Applications: IHC, ELISA, ICC/IF, Flow
Reactivity: Human, Mouse
Applications: IHC, WB, ICC/IF, IP, Simple Western
Reactivity: Human, Mouse, Rat
Applications: IHC, WB, ICC/IF, IP, ChIP, KD
Reactivity: Human, Mouse, Rat, Monkey, Primate
Applications: WB, Simple Western, ICFlow
Reactivity: Human

Recombinant Monoclonal Antibody.

Applications: WB
Reactivity: Human, Mouse, Rat, Canine, Primate, +1 More
Applications: ICFlow
Reactivity: Human, Mouse, Rat
Applications: IHC, WB, ICC/IF, IP
Reactivity: Human, Mouse, Rat

Recombinant Monoclonal Antibody.

Applications: WB
Reactivity: Human
Applications: IHC, WB, ICC/IF, IP
Reactivity: Human, Mouse, Rat, Zebrafish

Recombinant Monoclonal Antibody.

Applications: IHC, WB
Reactivity: Human, Mouse

Recombinant Monoclonal Antibody.

Applications: WB, ELISA, Func, MA, AP, PAGE
Applications: ICFlow, KO
Reactivity: Human, Mouse, Rat
Applications: IHC, WB, KO
Reactivity: Human, Mouse, Rat
Applications: ICFlow
Reactivity: Human, Mouse, Rat
Applications: WB
Reactivity: Human
Applications: IHC, WB, ELISA, ICC/IF
Reactivity: Human, Mouse, Rat
Applications: IHC, WB, ICC/IF, KD
Reactivity: Human
Applications: IHC, WB, KD
Reactivity: Human
Applications: ICFlow
Reactivity: Human
Applications: ICFlow
Reactivity: Human
Applications: ICFlow
Reactivity: Human

Recombinant Monoclonal Antibody.

Results Per Page
5 10 25 50
/ 8