Tie-2 Products
Tie-2, also known as Tek, is a transmembrane receptor tyrosine kinase (RTK) that functions as a receptor for Angiopoietin family proteins. It is expressed by embryonic and adult endothelial cells, hematopoietic stem cells, and a circulating population of proangiogenic monocytes. Tie-2 signaling is activated by Angiopoietins-1 and -4, while it can be either activated or inhibited by Angiopoietins-2 and -3.
Tie-2 plays an important role in maintaining vascular integrity by mediating endothelial cell-smooth muscle cell communication and inhibiting endothelial cell apoptosis. It is also required for the embryonic development of the endocardium. In addition, Tie-2 signaling mediates the quiescence of bone marrow stem cells in response to osteoblast-produced Angiopoietin-1. This quiescence is critical for maintaining an ongoing hematopoietic capability in the bone marrow.
Products:
228 results for "Tie-2" in Products
228 results for "Tie-2" in Products
Tie-2 Products
Tie-2, also known as Tek, is a transmembrane receptor tyrosine kinase (RTK) that functions as a receptor for Angiopoietin family proteins. It is expressed by embryonic and adult endothelial cells, hematopoietic stem cells, and a circulating population of proangiogenic monocytes. Tie-2 signaling is activated by Angiopoietins-1 and -4, while it can be either activated or inhibited by Angiopoietins-2 and -3.
Tie-2 plays an important role in maintaining vascular integrity by mediating endothelial cell-smooth muscle cell communication and inhibiting endothelial cell apoptosis. It is also required for the embryonic development of the endocardium. In addition, Tie-2 signaling mediates the quiescence of bone marrow stem cells in response to osteoblast-produced Angiopoietin-1. This quiescence is critical for maintaining an ongoing hematopoietic capability in the bone marrow.
Products:
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western, IHC, Block |
Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, IHC, CyTOF-ready, ICFlow |
Design and order Simple Plex cartridges tailor made to meet your needs with customizable Simple Plex Assay panels for the Ella platform.
| Applications: | Simple Plex |
| Sensitivity: | 40.2 pg/mL |
| Applications: | ELISA |
| Assay Range: | 125 - 8,000 pg/mL (Cell Culture Supernates, Tissue Homogenates, Serum, EDTA Plasma, Heparin Plasma) |
Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #83715 |
| Applications: | Flow |
Simple Plex Human Tie-2 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
| Applications: | Simple Plex |
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
Contains 4 membranes - each spotted in duplicate with 39 different RTK antibodies
| Source: | NS0 |
| Accession #: | Q02763 |
| Applications: | BA |
| Assay Range: | 156 - 10,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #83715 |
| Applications: | Flow |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, IHC |
| Source: | NS0 |
| Accession #: | NP_001099207 |
| Applications: | Bind |
Potent Tie2 inhibitor
| Chemical Name: | [3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluorosulfur |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #83715 |
| Applications: | WB, Flow |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, Simple Western |
![Western Blot: Tie-2 AntibodyBSA Free [NBP1-69753]](https://resources.bio-techne.com/images/products/Tie-2-Antibody-Western-Blot-NBP1-69753-img0006.jpg "Western Blot: Tie-2 AntibodyBSA Free [NBP1-69753]")
| Source: | NS0 |
| Accession #: | AAA61139.1 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #83704 |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #83711 |
| Applications: | WB |
| Source: | NS0 |
| Accession #: | CAA47857 |
| Applications: | Bind |
| Reactivity: | Zebrafish |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Block |
| Reactivity: | Zebrafish |
| Details: | Mouse IgG1 Monoclonal Clone #176222 |
| Applications: | WB, Block |
| Applications: | ELISA |
