92 results for "VHL" in Products
VHL Products
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #1066408 |
| Applications: | ICC |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #1066402 |
| Applications: | WB, Simple Western |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #1066409 |
| Applications: | IHC |
Functionalized VHL building block for copper-free click chemistry
| Chemical Name: | ((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl ((S)-14-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-12-oxo-3,6,9-trioxa-13-azahexadecyl)carbamate |
| Purity: | ≥90% (HPLC) |
Inhibitor of VHL; blocks interaction of VHL and HIF-α
| Chemical Name: | (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
VHL ligand with alkyl linker and terminal amine for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-C2-NH2 |
| Chemical Name: | (2S,4R)-1-((S)-2-(3-Aminopropanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand with alkyl linker and terminal amine for onward chemistry
| Chemical Name: | (2S,4R)-N-(2-(4-Aminobutoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand with alkyl linker and terminal amine for onward chemistry
| Chemical Name: | (2S,4R)-N-(2-((6-Aminohexyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand with alkyl linker and terminal acid for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-C2-COOH |
| Chemical Name: | 4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid |
| Purity: | ≥95% (HPLC) |
VHL ligand with alkyl linker and terminal acid for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-amido-C7-acid |
| Chemical Name: | 9-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-9-oxononanoic acid |
| Purity: | ≥95% (HPLC) |
Hydroxyl functionalized VHL ligand
| Chemical Name: | (2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
Functionalized VHL ligand for PROTACs
| Chemical Name: | (4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride |
| Purity: | ≥98% (HPLC) |
Fluorescent HIF-1α peptide; can be used to evaluate the effect of VHL binding on degradation activity
| Purity: | ≥95% (HPLC) |
VHL ligand with PEG linker and terminal amine for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-PEG2-NH2 |
| Chemical Name: | (2S,4R)-1-((S)-2-(2-(2-(2-Aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥95% (HPLC) |
VHL ligand with alkyl linker and terminal amine for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-C5-NH2 |
| Chemical Name: | (2S,4R)-1-((S)-2-(6-Aminohexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand with PEG linker and terminal amine for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-PEG6-NH2 |
| Chemical Name: | (2S,4R)-1-((S)-23-Amino-2-(tert-butyl)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand with alkyl linker and terminal amine for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-C9-NH2 |
| Chemical Name: | (2S,4R)-1-((S)-2-(10-Aminodecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand with alkyl linker and terminal acid for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-C3-COOH |
| Chemical Name: | 5-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentanoic acid |
| Purity: | ≥95% (HPLC) |
VHL ligand with alkyl linker and terminal amine for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-phenol-C6-NH2 |
| Chemical Name: | (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-N-(2-((6-aminohexyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand with alkyl linker and terminal amine for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-phenol-C4-NH2 |
| Chemical Name: | (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-N-(2-(4-aminobutoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand with alkyl linker and terminal amine for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-C7-NH2 |
| Chemical Name: | (2S,4R)-1-((S)-2-(8-Aminooctanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand with PEG linker and terminal amine for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-PEG3-NH2 |
| Chemical Name: | (2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand with alkyl linker and terminal amine for onward chemistry
| Alternate Names: | VH 032 - linker 8,(S,R,S)-AHPC-C2-NH2 |
| Chemical Name: | (2S,4R)-1-((S)-2-(7-Aminoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand with alkyl linker and terminal acid for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-C9-COOH |
| Chemical Name: | 11-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecanoic acid |
| Purity: | ≥95% (HPLC) |
