Spatial Biology with RNAscope

See More With RNAscope™ | Products and Applications | Spatial Insights in Health and Disease | Therapeutics Development | Customer Testimonials

Delivering Spatial Insights to Improve Lives

Bio-Techne is a global leader in spatial biology, delivering powerful multiomic solutions to reveal ground-breaking discoveries, accelerate the development of next-generation therapeutics, and deliver life changing diagnostics. Reveal new insights in cell phenotype and function with confidence using gold-standard RNAscope™ technology, proven Bio-Techne antibodies, and the fully automated Lunaphore COMET™ system.

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Many Spatial Questions. One Clear Answer.

Accurately detect RNA expression at single-molecule sensitivity and subcellular resolution.
Visualize and quantify any RNA. Select from mRNAs, ncRNAs, splice variants, reporters, transgenes and more.
Easily detect RNA and protein biomarkers on the same section for a comprehensive view of single-cell phenotype and function.
Characterize any organism or tissue with proven protocols.

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Spatial Biology Hub RNAscope Infographic

Featured Spatial Biology Products and Applications

Detection of cytokines, immune and tumor cells using an RNAscope RNA-protein multiomic panel of 4 marker proteins, CD4 (yellow), CD8 (white), PanCK (pink), FoxP3 (green), and 2 target RNA probes, IFNG (red), GZMB (turquoise) in human colon cancer tissue

Spatial Multiomics

Visualize cell phenotype and function with protease-free, same-slide codetection of protein and RNA.

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Lunaphore COMET™

Unlock the potential of spatial biology with unmatched hyperplex throughput, walk-away automation, and rapid, flexible panel design.

Discover COMET at Lunaphore.com

Profiling different cell types within the brain tumor microenvironment. Simultaneous detection of a panel of 3 marker proteins (CD8a, CD68, S100β) and 3 target RNA probes (CLDN5, CXCL10, TNFα) in brain tumor tissue.

Single Cell Validation

Visualize the spatial localization and activation states of novel cell subtypes.

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Reveal New Spatial Biology Insights in Health and Disease

Neuroscience

Spatially interrogate neuronal cell subtypes, central inflammatory responses, and networks of pain and addiction.

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Cancer

Uncover mechanisms underlying cancer initiation, progression, and therapeutic resistance.

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Inflammation

Quantify and characterize immune cell infiltration and activation including cytokine chemokine expression.

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Over 10K Spatial Biology Publications and Counting

Easily find peer-reviewed research articles for your gene or research area of interest. See how RNAscope can help you uncover new spatial interests to achieve your research goals.

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Accelerate Therapeutics Development

Gene Therapy

Visualize AAV vector and ASO/siRNA biodistribution, cellular tropism, and transduction efficiency in spatial context.

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Cell Therapy

Quantify infiltration and cellular activation of engineered cells in cancer and diseased tissues.

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Customer Success Stories

Ruchi Komal PhD, Research Fellow
SLCR, National Institute of Mental Health, NIH

RNAscope spatial analysis greatly improves our research by offering high-resolution visualization of gene expression within the SCN... validating discoveries from single-cell data, identifying rare cell populations, and facilitating gene co-expression analysis in situ.

Dr Denis Schapiro
Heidelberg University Hospital

The Lunaphore COMET™ system has enabled us to perform highly-multiplexed imaging of entire cross sections of mouse hearts with sub-cellular resolution. The flexible panel design accelerated antibody validation and measurements so that we can already perform spatial analysis of the heart at scale.

Dr Cheryl Stoddart, Ekaterina Maidji

The identification and anatomic location of HIV-infected cells and the effects of tissue environment on virus replication and viral gene expression are all critical for evaluating the pathogenesis of HIV infection and for developing cure strategies to eliminate HIV reservoirs. RNAscope in situ hybridization (ISH) has enabled us to visualize and quantify HIV RNA with single-copy resolution. For work supported by a Federal Contract with NIAID, NIH, we are using this state-of-the-art ISH technology in combination with immunohistochemistry to characterize the tissue and cellular compartments where the virus resides in HIV-infected humanized mice.

Spatial Biology

Delivering Spatial Insights to Improve Lives

See More With RNAscope™

Many Spatial Questions. One Clear Answer.

Search RNAscope Target and Control Probes