Decode Cancer With RNAscope™

Tumors are highly complex, comprising malignant cells surrounded by immune cells, endothelial cells and fibroblasts among others, with dynamic cross-talk.​

Inter- and intratumor heterogeneity occurs due to differences in expression of biomarker/therapeutic targets, genetic isoforms and cellular populations. Understanding the functional effect of heterogeneity on tumor initiation, progression and therapeutic resistance is vital for designing a suitable treatment strategy. Analyzing the complex spatial relationships among the different cell types within the tumor microenvironment requires a precise spatial platform.​

The RNAscope™ technology allows high sensitivity and spatial resolution providing pivotal single-cell imaging information to gain better insights into the complex and heterogeneous tumor microenvironment and its dynamics in cancer initiation, progression and metastasis. 

Tumor associated macrophages in breast cancer tissue. Protein: CD163 (pink), CD68 (green); RNA: CXCL10 (orange), IL1B (blue), IL10 (grey), TNFA (red).