Anti- Teprotumumab (Anti-Idiotype) Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB96341

R&D Systems, part of Bio-Techne

Key Product Details

Species Reactivity

Multi-Species

Applications

Binding Inhibition, Flow Cytometry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # 975547

View all Teprotumumab Antibodies »

Product Specifications

Immunogen

Full-length Teprotumumab

Specificity

Detects Teprotumumab in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for Anti- Teprotumumab (Anti-Idiotype) Antibody

Detection of Anti-IGFLR-1 (Teprotumumab) on Human MCF-7 cells antibody by Flow Cytometry.

Detection of Anti-IGFLR-1 (Teprotumumab) on Human MCF-7 cells by flow cytometry.

MCF-7 human cell line was stained with Human anti-Human IGFLR-1 (Teprotumumab) Monoclonal Antibody (Catalog # MAB9718) then Anti-Teprotumumab (Anti-Idiotype) (Catalog # MAB96341, filled histogram) or Mouse IgG2Aisotype control antibody(Catalog # MAB003, open histogram) followed by PE-conjugated anti-mouse IgG secondary antibody (Catalog # F0102B).
Anti-IGFLR-1 (Teprotumumab) binding to MCF-7 Human Cell Line is Blocked by Anti-Teprotumumab (Anti-Idiotype) Antibody.

Anti-IGFLR-1 (Teprotumumab) binding to MCF-7 Human Cell Line is Blocked by Anti-Teprotumumab (Anti-Idiotype) Antibody.

In a functional flow cytometry test, Biotinylated Anti-IGFLR-1 (Teprotumumab) (Catalog # FAB9718B) binds to MCF-7 human cell line (black dotted line). Binding is completely blocked (orange histogram) by 0.25 µg/mL of Anti-Teprotumumab (Anti-idiotype) Monoclonal Antibody (Catalog# MAB96341), but not by Normal Mouse IgG2A(Catalog # MAB003) (blue line). Cells were stained with APC-conjugated Streptavidin (Catalog # F0050).

Applications for Anti- Teprotumumab (Anti-Idiotype) Antibody

Application
Recommended Usage

Flow Cytometry

0.25 µg/106 cells
Sample: MCF-7 Human Cell line stained anti-IGFLR-1 (Teprotumumab ), Catalog # MAB9718

Binding Inhibition

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
Size / Price
Qty

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Teprotumumab

The anti-Teprotumumab antibody is an anti-Idiotype antibody raised against and selected for the antigenic determinants of the variable region of Teprotumumab. The antibody has been tested against a broad range of other biosimilars to ensure specificity. This highly specialized anti-idiotypic antibody can be used in a variety of pharmacokinetic (PK) assay formats.

Additional Teprotumumab Products

Product Documents for Anti- Teprotumumab (Anti-Idiotype) Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Anti- Teprotumumab (Anti-Idiotype) Antibody

For research use only

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