Skip to main content

BMP-15/GDF-9B Antibody (BMP15/4263) [Biotin]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-08876B

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

ELISA, Western Blot

Label

Biotin

Antibody Source

Monoclonal Mouse IgG1 Clone # BMP15/4263

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Product Specifications

Immunogen

Recognizes sequence SAEVTASSSKHSGPENNQC on the C-terminus of human BMP-15/GDF-9B (Uniprot: O95972)

Localization

Cytoplasmic (secreted)

Specificity

BMP15, also known as GDF9B, plays a crucial role in the regulation of fertility. Clone BMP15/4263 can be used to detect BMP15 expression and biosynthesis in various carcinoma progression studies.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for BMP-15/GDF-9B Antibody (BMP15/4263) [Biotin]

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: BMP-15/GDF-9B

BMPs are secreted signaling molecules that comprise a subfamily of the TGF-beta superfamily and were originally identified as regulators of cartilage and bone formation. There are at least 20 structurally and functionally related BMPs, most of which play roles in embryogenesis and morphogenesis of various tissues and organs. Biologically active BMPs are usually homodimers containing a characteristic cysteine knot structure. Heterodimers, BMP-2/BMP-7 and BMP-4/BMP-7 have also been suggested to exist and function in vivo. They are more potent inducers of bone formation than their respective homodimers. In addition, heterodimers, but not homodimers, are ventral mesoderm inducers. Heterodimer activity may be mediated by a different or additional receptor subtype.

Decapentaplegic (Dpp) is one of at least five TGF-beta superfamily ligands identified in the Drosophila genome. Dpp, a functional ortholog of mammalian BMP-2 and BMP-4, is a morphogen and plays an essential role in Drosophila development. Dpp regulates embryonic dorsal-ventral polarity and is required for gut morphogenesis and outgrowth and patterning of imaginal disks.

Long Name

Bone Morphogenetic Protein 15

Alternate Names

BMP15, GDF-9B

Gene Symbol

BMP15

Additional BMP-15/GDF-9B Products

Product Documents for BMP-15/GDF-9B Antibody (BMP15/4263) [Biotin]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for BMP-15/GDF-9B Antibody (BMP15/4263) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Loading...
Loading...
Loading...
Loading...