Recognizes the rat CD161 protein (also known as NKR-PI) a 60kD glycoprotein expressed on rat NK cells and T cell subpopulations. This competes with clone 3.2.3 for binding to antigen.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁

Applications for CD161 Antibody (10/78) [Janelia Fluor® 669]

Application

Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Frozen

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: CD161

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 (CD161) protein contains an extracellular domain with several motifs characteristic of C type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. In mouse the NKRP1 family has three members, NKRP1A, B and C, whilst in human only one member has been identified. The human protein has received the designation CD161, and the mouse proteins have been referred to as CD161a, b and c. Engagement of CD161c has been reported to have activating function in NK cells, whilst engagement of CD161b is inhibitory.

Alternate Names

CD161, CLEC5B, KLRB1, Ly59, NKR, NKRP1, NKRP1A

Gene Symbol

KLRB1

Additional CD161 Products

Product Documents for CD161 Antibody (10/78) [Janelia Fluor® 669]

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for CD161 Antibody (10/78) [Janelia Fluor® 669]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

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Flow Cytometry

CD161 Antibody (10/78) [Janelia Fluor® 669]

Novus Biologicals, part of Bio-Techne | Catalog # NB100-65297JF669

Key Product Details

Species Reactivity

Validated:

Applications

Label

Antibody Source

Concentration

View all CD161 Antibodies »

Product Summary for CD161 Antibody (10/78) [Janelia Fluor® 669]

Immunogen

Specificity

Clonality

Host

Isotype

Applications for CD161 Antibody (10/78) [Janelia Fluor® 669]

Flow Cytometry

Immunohistochemistry

Immunohistochemistry-Frozen

Immunoprecipitation

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

Concentration

Shipping

Stability & Storage

Background: CD161

Alternate Names

Gene Symbol

Additional CD161 Products

Product Documents for CD161 Antibody (10/78) [Janelia Fluor® 669]

Product Datasheets

COA

Certificate of Analysis

SDS

Product Specific Notices for CD161 Antibody (10/78) [Janelia Fluor® 669]

CONTACT INFORMATION

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