CD161 Antibody (10/78) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-80629

Novus Biologicals, part of Bio-Techne
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NBP2-80629
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Catalog #
BSA Free
NB100-65297
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Key Product Details

Species Reactivity

Rat

Applications

CyTOF-ready, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 10/78

Format

Azide and BSA Free

Concentration

1 mg/ml

View all CD161 Antibodies »

Product Specifications

Immunogen

Purified splenic NK cells from the LEW rat strain.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for CD161 Antibody (10/78) - Azide and BSA Free

Flow Cytometry: CD161 Antibody (10/78) - Azide and BSA Free [NBP2-80629]

Flow Cytometry: CD161 Antibody (10/78) - Azide and BSA Free [NBP2-80629]

Flow Cytometry: CD161 Antibody (10/78) - Azide and BSA Free [NBP2-80629] - Rat splenocytes were stained with Anti-Rat CD3 APC-conjugated Monoclonal Antibody and either (A) Mouse Anti-Rat CD161 Monoclonal Antibody (Catalog# NB100-65297) or (B) Mouse IgG1 Isotype control (Catalog# MAB002) followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog# F0102B). View our protocol for Staining Membrane-associated Proteins.

Applications for CD161 Antibody (10/78) - Azide and BSA Free

Application
Recommended Usage

Flow Cytometry

1:10-1:1000

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Frozen

1:10-1:500

Immunoprecipitation

1:10-1:500

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CD161

CD161, also known as KLRB1, NK1.1, and NKR-P1A is a 40 kDa type II transmembrane glycoprotein that contains one C-type lectin domain in its extracellular region. CD161 is expressed as a disulfide-linked dimer on the surface of Th17 cells and NK cells as well as on subsets of CD1-restricted T cells, intestinal NT cells, peripheral memory T cells, monocytes, and dendritic cells. It binds to OCIL/CLEC2d, leading to an inhibition of NK cell-mediated cytotoxicity and IFN-gamma secretion. Alternatively, CD161 can enhance TCR activation to CD1d ligation. CD161+ cell populations are depleted in ulcerative colitis, Grave's disease, and AIDS, although CD161+ T cells are activated during asthmatic attacks. Additional related proteins are expressed in mouse but not human: the inhibitory NKR-P1B and D, and the stimulatory NKR-P1A, C, and F.

Alternate Names

CD161, CLEC5B, KLRB1, Ly59, NKR, NKRP1, NKRP1A

Gene Symbol

KLRB1

Additional CD161 Products

Product Documents for CD161 Antibody (10/78) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for CD161 Antibody (10/78) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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