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IL-18/IL-1F4 Antibody (GSK 1070806) - Humanized

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-27989

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Clone # GSK 1070806

Concentration

LYOPH mg/ml

Product Specifications

Immunogen

IL-18

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Endotoxin Level

< 0.001EU/ug,determined by LAL method.

Description

Expressed from CHO. The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

Scientific Data Images for IL-18/IL-1F4 Antibody (GSK 1070806) - Humanized

IL-18/IL-1F4 Antibody (GSK 1070806) - Humanized

Flow Cytometry: IL-18/IL-1F4 Antibody (GSK 1070806) - Humanized[NBP3-27989] -

IL-18/IL-1F4 Antibody (GSK 1070806) - Humanized-induced FACS Blocking activity was evaluated using Hu IL-18R alpha-Hu IL-18R beta-HEK293-A8. The IC50 was approximately 0.335 ug/mL.

Applications for IL-18/IL-1F4 Antibody (GSK 1070806) - Humanized

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: IL-18/IL-1F4

The protein encoded by the IL18 gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. (provided by RefSeq)

Long Name

Interleukin 18

Alternate Names

IGIF, IL-1F4, IL-1g, IL18

Gene Symbol

IL18

UniProt

Additional IL-18/IL-1F4 Products

Product Documents for IL-18/IL-1F4 Antibody (GSK 1070806) - Humanized

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for IL-18/IL-1F4 Antibody (GSK 1070806) - Humanized

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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