LDLR Antibody (C7) [DyLight 650]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-78159C

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human, Rat, Porcine, Bovine

Applications

Electron Microscopy, ELISA, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunoprecipitation, In vitro assay, Proximity Ligation Assay, Radioimmunoassay, Western Blot

Label

DyLight 650 (Excitation = 652 nm, Emission = 672 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # C7

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all LDLR Antibodies »

Product Specifications

Immunogen

Partially purified bovine LDL receptor [Swiss-Prot# P01131].

Localization

Cell membrane/cell surface, endomembrane system, endosomes, lysosome, clathrin-coated pit, and Golgi apparatus

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for LDLR Antibody (C7) [DyLight 650]

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Electron Microscopy

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Frozen

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

In vitro assay

Optimal dilutions of this antibody should be experimentally determined.

Proximity Ligation Assay

Optimal dilutions of this antibody should be experimentally determined.

Radioimmunoassay

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: LDLR

In cholesterol homeostasis regulation, the low density lipoprotein receptor is a critical factor. LDLR binds and internalizes LDL, then directs LDL toward cellular synthetic machinery, or towards destructive pathways for release or recycling. When alternatively spliced forms of the LDLR are present in cells, its native enzymatic activity is often reduced. This reduction in enzyme function is often related to the formation of atherosclerotic plaques. A common Class 5 mutation in LDLR results in it being able to bind and internalize LDL, but subsequently unable to release it to endosomes for recycling. LDLR is dependent upon the activity of PCSK9 for regulating its activity. In the liver, the LDLR is degraded when signaled by PCSK9, which increases the probability of high hepatic levels of LDL. In the brain, PCSK9 downregulates LDLR levels during development and following adult brain injury, thus demonstrating the dual functionality of this critical receptor.

Long Name

Low Density Lipoprotein Receptor

Alternate Names

LDL R

Gene Symbol

LDLR

Additional LDLR Products

Product Documents for LDLR Antibody (C7) [DyLight 650]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for LDLR Antibody (C7) [DyLight 650]



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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