Mitofusin 1 Antibody (11E9-1H12) [Biotin]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-71775B

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Knockout Validated, Western Blot

Label

Biotin

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # 11E9-1H12

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Mitofusin 1 Antibodies »

Product Specifications

Immunogen

Mouse Mitofusin 1

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 23658809). Human reactivity reported in scientific literature (PMID: 24710686, 24928681).

Localization

Mitochondrion outer membrane; Multi-pass membrane protein

Marker

Mitochondrial Fusion Marker

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Applications for Mitofusin 1 Antibody (11E9-1H12) [Biotin]

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Knockout Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Mitofusin 1

When mitochondria are impaired by genetic mutations or viral insertions, they are selectively isolated and destroyed by complicated intracellular mechanisms. The mitochondrial fusion-promoting factor MFN1 is a critical contributor to mediating this selective process. MFN1 is ubiquinated by PINK1 after its recruitment by Parkin, and this post-translational modification is critical in catalyzing mitochondrial repair or removal by other cellular mechanisms. In both Parkinson's and Alzheimer's disease, as well as when viruses attempt to replicate, mitochondrial fission and mitophagy are erroneously regulated due to the mutation or elimination of MFN1. This disruption of mitochondrial repair and regulation is implicated in many of the phenotypic demonstrations of neurodegenerative disorders.

Alternate Names

hfzo1, hfzo2, MFN1

Gene Symbol

MFN1

Additional Mitofusin 1 Products

Product Documents for Mitofusin 1 Antibody (11E9-1H12) [Biotin]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Mitofusin 1 Antibody (11E9-1H12) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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