SHP-1 Antibody (PTPN6/7544)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26718

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # PTPN6/7544

Concentration

0.2 mg/ml

View all SHP-1 Antibodies »

Product Specifications

Immunogen

Recombinant fragment (around aa395-595) of human SHP-1 protein (exact sequence is proprietary)

Localization

Cytoplasm, Nucleus, In neurons, translocates into the nucleus after treatment with angiotensin II,

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Description

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C. Non-hazardous. No MSDS required.

Scientific Data Images for SHP-1 Antibody (PTPN6/7544)

SHP-1 Antibody (PTPN6/7544)

Immunohistochemistry-Paraffin: SHP-1 Antibody (PTPN6/7544) [NBP3-26718 ] -

Formalin-fixed, paraffin-embedded human tonsil stained with SHP-1 Antibody (PTPN6/7544). Inset: PBS instead of primary antibody; secondary only negative control.

Applications for SHP-1 Antibody (PTPN6/7544)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1-2ug/ml for 30 minutes at RT
Application Notes
Immunohistochemistry-Paraffin 1-2ug/ml for 30 minutes at RT. Optimal dilution for a specific application should be determined.. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: SHP-1

The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration.

Long Name

Src Homology Region 2 Domain Phosphatase 1

Alternate Names

HCPH, PTP1C, PTPN6, SHP1

Gene Symbol

PTPN6

Additional SHP-1 Products

Product Documents for SHP-1 Antibody (PTPN6/7544)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SHP-1 Antibody (PTPN6/7544)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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