SHP-1 Antibody (PTPN6/7544) [DyLight 755]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-27000IR

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Unconjugated

NBP3-26718

Alexa Fluor 350

NBP3-27000AF350

Alexa Fluor 405

NBP3-27000AF405

Alexa Fluor 488

NBP3-27000AF488

Alexa Fluor 532

NBP3-27000AF532

Alexa Fluor 594

NBP3-27000AF594

Alexa Fluor 647

NBP3-27000AF647

Alexa Fluor 700

NBP3-27000AF700

Alexa Fluor 750

NBP3-27000AF750

Allophycocyanin

NBP3-27000APC

Biotin

NBP3-27000B

CoraFluor 1

NBP3-27000CL1

DyLight 350

NBP3-27000UV

DyLight 405

NBP3-27000V

DyLight 488

NBP3-27000G

DyLight 550

NBP3-27000R

DyLight 594

NBP3-27000DL594

DyLight 650

NBP3-27000C

DyLight 680

NBP3-27000FR

FITC

NBP3-27000F

HRP

NBP3-27000H

Janelia Fluor 525

NBP3-27000JF525

Janelia Fluor 549

NBP3-27000JF549

Janelia Fluor 585

NBP3-27000JF585

Janelia Fluor 635

NBP3-27000JF635

Janelia Fluor 646

NBP3-27000JF646

Janelia Fluor 669

NBP3-27000JF669

mFluor Violet 450 SE

NBP3-27000MFV450

mFluor Violet 500 SE

NBP3-27000MFV500

mFluor Violet 610 SE

NBP3-27000MFV610

PE

NBP3-27000PE

PerCP

NBP3-27000PCP

Forumulation

Catalog #

Azide and BSA Free

NBP3-27000

Product Summary
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry-Paraffin

Label

DyLight 755 (Excitation = 754 nm, Emission = 776 nm)

Antibody Source

Monoclonal Mouse IgG₁ kappa Clone # PTPN6/7544

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SHP-1 Antibodies »

Product Summary for SHP-1 Antibody (PTPN6/7544) [DyLight 755]

Immunogen

Recombinant fragment (around aa395-595) of human SHP-1 protein (exact sequence is proprietary)

Localization

Cytoplasm, Nucleus, In neurons, translocates into the nucleus after treatment with angiotensin II,

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁ kappa

Applications for SHP-1 Antibody (PTPN6/7544) [DyLight 755]

Application

Recommended Usage

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: SHP-1

The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration.

Long Name

Src Homology Region 2 Domain Phosphatase 1

Alternate Names

HCPH, PTP1C, PTPN6, SHP1

Gene Symbol

PTPN6

Additional SHP-1 Products

Product Documents for SHP-1 Antibody (PTPN6/7544) [DyLight 755]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for SHP-1 Antibody (PTPN6/7544) [DyLight 755]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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