Overcome Your Cell Culture Challenges with AI Modified Proteins by R&D Systems
Discover the future of protein design with R&D Systems AI (artificial intelligence) modified proteins, an advanced solution to overcoming cell culture challenges. These state-of-the-art proteins mirror the biological functionality of their wild-type counterparts while introducing optimized features to meet the evolving demands of cellular therapy workflows and research applications.
Engineered using cutting-edge technologies such as generative AI, protein library evolution, and rational design, these innovative proteins deliver critical benefits resulting in enhanced cell culture performance, including:
- Optimized cell expansion
- Superior biological activity
- Streamlined workflows and a path to clinical applications
With tailored functionalities such as hyperactivity, improved receptor affinities, and increased heat stability, our new designer cytokines and growth factors represent a breakthrough in cell culture innovation.
Proteins Designed for Solubility
Engineered to be water-soluble and easier to purify, our line of Wnt/R-Spondin Agonist Proteins effectively activate canonical Wnt signaling.
Proteins Designed for Stability
Engineered for stability at high temperatures, our line of heat stable proteins maintain high bioactivity in cell culture for longer periods.
Proteins Designed for Hyperactivity
Engineered for enhanced bioactivity, our hyperactive proteins demonstrate superior performance compared to wild type protein.
Wnt/R-Spondin Agonist Proteins
Key reagents for advancing stem cell research, organoid development, and regenerative medicine, these proteins offer:
- All-in-One Activation: Reduce experimental complexity with a single, cost-effective protein
- Streamline Workflows: Save time with a well-defined reagent to substitute for conditioned media or the addition of two individual proteins
- Reliable Performance: Effectively promotes Wnt receptor activation and canonical Wnt signaling
- Easier to Purify: Amenable to media formulations due to increased water-solubility
IL-2 Heat Stable Agonist Protein
Ideal for cellular therapy applications such as CAR T cell or TIL expansion, this protein ensures:
- Improved Stability: Able to withstand high temperatures and extended culture durations due to a synthetic core designed to strengthen the protein's structure
- Enhanced Consistency: Increased stability in media over extended culture durations allows greater consistency throughout production processes
- Reliable Performance: Promotes comparable CD8+/CD4+ T cell outgrowth as the wild type protein, with similar T cell phenotypes
FGF basic Heat Stable Protein
Formatted to support cell therapy manufacturing and advanced research, this protein provides:
- Improved Stability: Retains higher activity than wild-type FGF basic at 37 °C, allowing it to withstand extended culture durations
- Enhanced Consistency: Improved stability over long culture periods means greater consistency throughout cell culture
- Seamless Path to Clinic: Our FGF basic Heat Stable protein shows equivalent bioactivity between RUO, Animal-Free and GMP proteins, providing performance continuity from research to clinical applications
Activin A Hyperactive Protein
Optimized for superior performance in regenerative medicine cell differentiation applications, this protein gives:
- Enhanced Activity: Cost-effective protein provides 4-fold higher activity than wild type, allowing less protein to be used to achieve the same potency
- Confidence In Performance: Promotes efficient endoderm differentiation in human iPSC lines
- Reliable Results: Efficient derivation of PDX1+/NKX6.1+ pancreatic progenitors that is comparable to the wild-type protein