CDC2/CDK1 Products
CDC2 (Cell Division Cycle 2), also known as CDK1 (Cyclin Dependent Kinase 1), is a member of the CDK family of serine/threonine kinases. The CDKs are important regulators of cell cycle progression and their activities are largely controlled by association with Cyclins, and activating and inhibitory phosphorylations. Entry into mitosis is initiated by CDC2. Full activation of CDC2 requires phosphorylation at T161 and association with CyclinB. In contrast, phosphorylation of CDC2 at Y15 and T14 during the G2-phase of the cell cycle inhibits activity, and dephosphorylation of Y15 and T14 by CDC25 phosphatase during late G2 restores activity.
97 results for "CDC2/CDK1" in Products
97 results for "CDC2/CDK1" in Products
CDC2/CDK1 Products
CDC2 (Cell Division Cycle 2), also known as CDK1 (Cyclin Dependent Kinase 1), is a member of the CDK family of serine/threonine kinases. The CDKs are important regulators of cell cycle progression and their activities are largely controlled by association with Cyclins, and activating and inhibitory phosphorylations. Entry into mitosis is initiated by CDC2. Full activation of CDC2 requires phosphorylation at T161 and association with CyclinB. In contrast, phosphorylation of CDC2 at Y15 and T14 during the G2-phase of the cell cycle inhibits activity, and dephosphorylation of Y15 and T14 by CDC25 phosphatase during late G2 restores activity.
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Western Blot: CDC2/CDK1 [p Thr161] Antibody [NB100-81837]](https://resources.bio-techne.com/images/products/CDC2-CDK1-[p-Thr161]-Antibody-Western-Blot-NB100-81837-img0005.jpg "Western Blot: CDC2/CDK1 [p Thr161] Antibody [NB100-81837]")
| Reactivity: | Human, Monkey, Bovine, Rat (Negative), Mouse (Negative), +3 More |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #POH-1; same as cdc2.1 |
| Applications: | IHC, WB |
![Western Blot: CDC2/CDK1 Antibody (POH-1; same as cdc2.1) [NBP2-34331]](https://resources.bio-techne.com/images/products/CDC2-CDK1-Antibody-POH-1;-same-as-cdc2-1-Western-Blot-NBP2-34331-img0003.jpg "Western Blot: CDC2/CDK1 Antibody (POH-1; same as cdc2.1) [NBP2-34331]")
| Reactivity: | Human, Monkey, Bovine, Rat (Negative), Mouse (Negative), +5 More |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #CDK1/873 |
| Applications: | IHC, WB |
![Western Blot: CDC2/CDK1 Antibody (CDK1/873) [NBP2-44915]](https://resources.bio-techne.com/images/products/CDC2-CDK1-Antibody-CDK1-873-Western-Blot-NBP2-44915-img0002.jpg "Western Blot: CDC2/CDK1 Antibody (CDK1/873) [NBP2-44915]")
| Reactivity: | Human, Monkey, Bovine, Rat (Negative), Mouse (Negative), +5 More |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #CDK1/873 |
| Applications: | IHC, WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Immunohistochemistry-Paraffin: CDC2/CDK1 Antibody [NBP1-85729]](https://resources.bio-techne.com/images/products/CDC2-CDK1-Antibody-Immunohistochemistry-Paraffin-NBP1-85729-img0015.jpg "Immunohistochemistry-Paraffin: CDC2/CDK1 Antibody [NBP1-85729]")
| Reactivity: | Human, Mouse, Rat, Monkey, Primate |
| Details: | Mouse IgG1 Monoclonal Clone #2G9 |
| Applications: | IHC, WB, ELISA, ICC/IF |
![Western Blot: CDC2/CDK1 Antibody (2G9)BSA Free [NBP2-37626]](https://resources.bio-techne.com/images/products/CDC2-CDK1-Antibody-2G9-Western-Blot-NBP2-37626-img0002.jpg "Western Blot: CDC2/CDK1 Antibody (2G9)BSA Free [NBP2-37626]")
| Reactivity: | Human, Mouse, Xenopus |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: CDC2/CDK1 [p Tyr15] Antibody [NB500-142]](https://resources.bio-techne.com/images/products/Cdc2-[p-Tyr15]-Antibody-Western-Blot-NB500-142-img0001.jpg "Western Blot: CDC2/CDK1 [p Tyr15] Antibody [NB500-142]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2a Lambda Monoclonal Clone #8F1 |
| Applications: | IHC, WB, ELISA |
![Western Blot: CDC2/CDK1 Antibody (8F1) [H00000983-M04]](https://resources.bio-techne.com/images/products/CDC2-CDK1-Antibody-8F1-Western-Blot-H00000983-M04-img0011.jpg "Western Blot: CDC2/CDK1 Antibody (8F1) [H00000983-M04]")
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #1A4-1A9 |
| Applications: | IHC, WB, ELISA, ICC/IF |
![Western Blot: CDC2/CDK1 Antibody (1A4-1A9) [H00000983-M01]](https://resources.bio-techne.com/images/products/CDC2-CDK1-Antibody-1A4-1A9-Western-Blot-H00000983-M01-img0011.jpg "Western Blot: CDC2/CDK1 Antibody (1A4-1A9) [H00000983-M01]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #PSH03-42 |
| Applications: | IHC, WB, ICC/IF, Flow |
![CDC2/CDK1 [p Thr161] Antibody (PSH03-42)](https://resources.bio-techne.com/images/products/nbp3-32753_rabbit-cdc2-cdk1-p-thr161-mab-psh03-42-288202412442960.jpg "Western Blot: CDC2/CDK1 [p Thr161] Antibody (PSH03-42) [NBP3-32753]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #6R1O7 |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: CDC2/CDK1 [p Thr14] Antibody [NBP3-13300]](https://resources.bio-techne.com/images/products/CDC2-CDK1-[p-Thr14]-Antibody-Western-Blot-NBP3-13300-img0002.jpg "Western Blot: CDC2/CDK1 [p Thr14] Antibody [NBP3-13300]")
| Applications: | ELISA |
| Applications: | PAGE |
![SDS-PAGE: Recombinant Human CDC2/CDK1 His Protein [NBP2-52017]](https://resources.bio-techne.com/images/products/CDC2-CDK1-Recombinant-Protein-SDS-Page-NBP2-52017-img0001.jpg "SDS-PAGE: Recombinant Human CDC2/CDK1 His Protein [NBP2-52017]")
| Reactivity: | S. pombe |
| Details: | Mouse IgG2B Monoclonal Clone #Y100.4 |
| Applications: | WB |
| Applications: | WB |
![Western Blot: CDC2/CDK1 Overexpression Lysate [NBL1-08991]](https://resources.bio-techne.com/images/products/Cdc2-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-08991-img0002.jpg "Western Blot: CDC2/CDK1 Overexpression Lysate [NBL1-08991]")
| Reactivity: | Xenopus, Mammal |
| Details: | Mouse IgG1 Monoclonal Clone #CP3.2 |
| Applications: | WB, ELISA |
Recombinant Monoclonal
| Reactivity: | Human |
| Details: | Rabbit Monoclonal Clone #BLR101H |
| Applications: | WB, IP |
![Immunoprecipitation: CDC2/CDK1 Antibody (BLR101H) [NBP3-14693]](https://resources.bio-techne.com/images/products/CDC2-CDK1-Antibody-Immunoprecipitation-NBP3-14693-img0001.jpg "Immunoprecipitation: CDC2/CDK1 Antibody (BLR101H) [NBP3-14693]")
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #3V7A1 |
| Applications: | WB, ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #6P7X9 |
| Applications: | WB, ELISA |
| Applications: | PAGE |
![SDS-PAGE: Recombinant Human CDC2/CDK1 His Protein [NBP2-51886]](https://resources.bio-techne.com/images/products/CDC2-CDK1-Recombinant-Protein-SDS-Page-NBP2-51886-img0001.jpg "SDS-PAGE: Recombinant Human CDC2/CDK1 His Protein [NBP2-51886]")
| Applications: | AC |
| Reactivity: | S. pombe |
| Details: | Mouse IgG2B Monoclonal Clone #Y100.4 |
| Applications: | WB |
Cdk inhibitor; potently inhibits cdk1 and cdk2; also inhibits CK1; acts as molecular glue
| Chemical Name: | (2R)-2-[[9-(Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-1-butanol trihydrochloride |
| Purity: | ≥99% |
α1 and α2B antagonist; also MT3 antagonist
| Chemical Name: | 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride |
| Purity: | ≥99% (HPLC) |
