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Fc gamma RIIIA/CD16a Products

Fc gamma RIIIA/CD16a is a low/intermediate affinity activating receptor for polyvalent immune-complexed IgG. It is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody-dependent cytotoxicity, and clearance of immune complexes. It is expressed on NK cells, T cells, monocytes, and macrophages. It is closely related to the GPI-linked Fc gamma RIIIB which is expressed on neutrophils and eosinophils.

Surface expression requires interaction with an accessory chain, either the common gamma chain or CD3 zeta. Shed forms of both Fc gamma RIIIA and Fc gamma RIIIB can be generated by proteolytic cleavage and retain binding activity. Soluble Fc gamma RIII circulates in normal plasma and is elevated in rheumatoid arthritis and in coronary artery diseases.

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131 results for "Fc gamma RIIIA/CD16a" in Products

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131 results for "Fc gamma RIIIA/CD16a" in Products

Fc gamma RIIIA/CD16a Products

Fc gamma RIIIA/CD16a is a low/intermediate affinity activating receptor for polyvalent immune-complexed IgG. It is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody-dependent cytotoxicity, and clearance of immune complexes. It is expressed on NK cells, T cells, monocytes, and macrophages. It is closely related to the GPI-linked Fc gamma RIIIB which is expressed on neutrophils and eosinophils.

Surface expression requires interaction with an accessory chain, either the common gamma chain or CD3 zeta. Shed forms of both Fc gamma RIIIA and Fc gamma RIIIB can be generated by proteolytic cleavage and retain binding activity. Soluble Fc gamma RIII circulates in normal plasma and is elevated in rheumatoid arthritis and in coronary artery diseases.

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Analyzed by SEC-MALS, Isoform V176, His-tag

Low-affinity V176F polymorphic variant

Applications: BA, BA

Biotinylated Isoform V176

Applications: IHC, Flow, IP, CyTOF-ready
Reactivity: Human, Primate
Applications: Flow
Reactivity: Human, Primate, Porcine
Applications: BA
Applications: IHC, ELISA
Reactivity: Human, Cynomolgus Monkey
Applications: ELISA
Applications: IHC, Flow
Reactivity: Human
Applications: WB, ELISA
Reactivity: Human, Mouse, Rat
Applications: IHC
Reactivity: Human
Applications: ELISA, ICC/IF
Reactivity: Human

Recombinant monoclonal antibody expressed in HEK293F cells

Applications: WB
Applications: WB
Applications: AC
Applications: WB, ELISA, IP
Reactivity: Rat
Applications: IHC, ELISA
Reactivity: Human, Cynomolgus Monkey
Applications: IHC, ELISA
Reactivity: Human, Cynomolgus Monkey
Applications: WB, ELISA, IP
Reactivity: Rat
Applications: IHC, Flow
Reactivity: Human
Applications: IHC, Flow
Reactivity: Human
Applications: IHC, Flow, IP, CyTOF-ready
Reactivity: Human, Primate
Applications: IHC, Flow, IP, CyTOF-ready
Reactivity: Human, Primate
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