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Smad2 Products

Smads are a family of intracellular proteins that mediate signaling by members of the TGF-beta superfamily. Smads are divided into three distinct subgroups based on their different roles in TGF-beta family signal transduction: R-Smads (receptor-regulated), Co-Smads (common partner), and I-Smads (inhibitory). In general, activation of TGF-beta superfamily serine/threonine kinase receptors leads to the phosphorylation of R-Smads (Smads1, 2, 3, 5, and 8). This is followed by recruitment of the Co-Smad (Smad-4) into an R-Smad/Co-Smad complex that translocates to the nucleus to regulate gene expression. I-Smads (Smad6 and Smad7) antagonize this signaling pathway by preventing R-Smads from interacting with the receptor, or by competing with Co-Smads for the generation of R-Smad/Co-Smad complexes.

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55 results for "Smad2" in Products

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55 results for "Smad2" in Products

Smad2 Products

Smads are a family of intracellular proteins that mediate signaling by members of the TGF-beta superfamily. Smads are divided into three distinct subgroups based on their different roles in TGF-beta family signal transduction: R-Smads (receptor-regulated), Co-Smads (common partner), and I-Smads (inhibitory). In general, activation of TGF-beta superfamily serine/threonine kinase receptors leads to the phosphorylation of R-Smads (Smads1, 2, 3, 5, and 8). This is followed by recruitment of the Co-Smad (Smad-4) into an R-Smad/Co-Smad complex that translocates to the nucleus to regulate gene expression. I-Smads (Smad6 and Smad7) antagonize this signaling pathway by preventing R-Smads from interacting with the receptor, or by competing with Co-Smads for the generation of R-Smad/Co-Smad complexes.

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Applications: WB, Simple Western, IHC, ChIP, ICC
Reactivity: Human, Mouse
Applications: WB
Reactivity: Human

Recombinant Monoclonal Antibody.

Applications: IHC, WB, ICC/IF
Reactivity: Human, Mouse, Rat, Canine, Chicken, +1 More
Applications: WB, IHC
Reactivity: Drosophila
Applications: IHC, WB, ELISA, ICC/IF, Flow
Reactivity: Human
Applications: IHC, WB, ELISA, ICC/IF, KO
Reactivity: Human, Mouse, Rat
Applications: IHC, WB, ICC/IF
Reactivity: Human
Applications: IHC, WB, ICC/IF
Reactivity: Human, Mouse, Rat
Applications: IHC
Reactivity: Human
Applications: ICC
Reactivity: Human
Applications: IHC, WB, ELISA
Reactivity: Human, Mouse, Rat
Applications: WB, ICC/IF, IP
Reactivity: Human, Mouse, Rat

Recombinant Monoclonal Antibody

Applications: IHC, WB, Simple Western
Reactivity: Human, Mouse, Rat
Applications: WB
Reactivity: Human, Mouse, Rat

Recombinant Monoclonal Antibody

Applications: WB, ICC/IF, Flow
Reactivity: Human, Mouse
Applications: ELISA
Applications: WB
Applications: ELISA
Applications: WB, ELISA
Reactivity: Human
Applications: WB
Reactivity: Human
Applications: WB, ELISA
Reactivity: Human

Recombinant monoclonal antibody expressed in HEK293F cells

Applications: ELISA, ICC/IF
Reactivity: Human

Recombinant monoclonal antibody expressed in HEK293F cells

Applications: ELISA
Applications: WB
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