Tyk2 Products
Tyk2 belongs to the Janus family of intracellular tyrosine kinases that are activated by receptors for many cytokines. Activation of Tyk2 occurs via phosphorylation at two adjacent tyrosine residues within the kinase domain. Tyk2 is required for interferon-mediated tyrosine phosphorylation of STAT3 and interferon a receptor 1. Mice lacking Tyk2 are susceptible to parasitic infection but resistant to autoimmune arthritis.
18 results for "Tyk2" in Products
18 results for "Tyk2" in Products
Tyk2 Products
Tyk2 belongs to the Janus family of intracellular tyrosine kinases that are activated by receptors for many cytokines. Activation of Tyk2 occurs via phosphorylation at two adjacent tyrosine residues within the kinase domain. Tyk2 is required for interferon-mediated tyrosine phosphorylation of STAT3 and interferon a receptor 1. Mice lacking Tyk2 are susceptible to parasitic infection but resistant to autoimmune arthritis.
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Flow |
![Western Blot: Tyk2 Antibody [NBP2-76968]](https://resources.bio-techne.com/images/products/Tyk2-Antibody-Western-Blot-NBP2-76968-img0001.jpg "Western Blot: Tyk2 Antibody [NBP2-76968]")
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #6G12 |
| Applications: | IHC, WB, ELISA, ICC/IF, IP |
![Western Blot: Tyk2 Antibody (6G12) [H00007297-M01]](https://resources.bio-techne.com/images/products/Tyk2-Antibody-6G12-Western-Blot-H00007297-M01-img0014.jpg "Western Blot: Tyk2 Antibody (6G12) [H00007297-M01]")
| Reactivity: | Human |
| Details: | Mouse IgG3 Monoclonal Clone #307214 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #6H1 |
| Applications: | IHC, WB, ELISA |
![Western Blot: Tyk2 Antibody (6H1) [H00007297-M03]](https://resources.bio-techne.com/images/products/Tyk2-Antibody-6H1-Western-Blot-H00007297-M03-img0014.jpg "Western Blot: Tyk2 Antibody (6H1) [H00007297-M03]")
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: Tyk2 Antibody [H00007297-D01P]](https://resources.bio-techne.com/images/products/Tyk2-Antibody-Western-Blot-H00007297-D01P-img0003.jpg "Western Blot: Tyk2 Antibody [H00007297-D01P]")
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #5A4 |
| Applications: | IHC, WB, ELISA, ICC/IF |
![Western Blot: Tyk2 Antibody (5A4) [H00007297-M02]](https://resources.bio-techne.com/images/products/Tyk2-Antibody-5A4-Western-Blot-H00007297-M02-img0011.jpg "Western Blot: Tyk2 Antibody (5A4) [H00007297-M02]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
![Western Blot: Tyk2 Antibody [NBP1-32450]](https://resources.bio-techne.com/images/products/Tyk2-Antibody-Western-Blot-NBP1-32450-img0009.jpg "Western Blot: Tyk2 Antibody [NBP1-32450]")
| Reactivity: | Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA |
![Western Blot: Tyk2 [p Tyr1055, p Tyr1054] AntibodyBSA Free [NBP3-16896]](https://resources.bio-techne.com/images/products/Tyk2-[p-Tyr1055-p-Tyr1054]-Antibody-Western-Blot-NBP3-16896-img0001.jpg "Western Blot: Tyk2 [p Tyr1055, p Tyr1054] AntibodyBSA Free [NBP3-16896]")
| Applications: | WB, ELISA, MA, AP |
| Applications: | ELISA |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
![Western Blot: Tyk2 Antibody [NBP1-87825]](https://resources.bio-techne.com/images/products/Tyk2-Antibody-Western-Blot-NBP1-87825-img0012.jpg "Western Blot: Tyk2 Antibody [NBP1-87825]")
| Applications: | WB |
| Applications: | AC |
Potent JAK inhibitor
| Alternate Names: | Tofacitinib citrate |
| Chemical Name: | (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile citrate |
| Purity: | ≥99% (HPLC) |
Potent TYK2 inhibitor
| Chemical Name: | 2-Chloro-4-cyano-6-fluoro-N-[2-[[[(1R,2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]benzamide |
| Purity: | ≥98% (HPLC) |
Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable
| Alternate Names: | JAK inhibitor I |
| Chemical Name: | 2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one |
| Purity: | ≥98% (HPLC) |
