Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. DOK2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. DOK2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung. Expression of bcr/abl induces additional tyrosine phosphorylation of the DOK1 and DOK2 proteins and their association with Ras-GAP. Thus, it is suspected that DOK association regulates GAP activity toward Ras and that the DOK proteins serve as mediators of bcr-abl signaling. The role of DOK proteins in bcr-abl regulation may also be implicated in chronic myelogenous leukemia (CML), which is characterized by a Philadelphia chromosome translocation t(9;22). Such a mutation would result in a p210-bcr/abl chimeric protein-tyrosine kinase which has been found in many CML cases.

Alternate Names

docking protein 2, docking protein 2, 56kD, docking protein 2, 56kDa, Dok-2, Downstream of tyrosine kinase 2, p56(dok-2), P56DOK, p56dok-2

Gene Symbol

DOK2

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Product Documents for DOK2 Antibody (OTI1A4) [DyLight 650]

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SDS

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Product Specific Notices for DOK2 Antibody (OTI1A4) [DyLight 650]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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DOK2 Antibody (OTI1A4) [DyLight 650]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-71407C

Key Product Details

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Applications for DOK2 Antibody (OTI1A4) [DyLight 650]

Flow Cytometry

Immunocytochemistry/ Immunofluorescence

Formulation, Preparation, and Storage

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Background: DOK2

Alternate Names

Gene Symbol

Additional DOK2 Products

Product Documents for DOK2 Antibody (OTI1A4) [DyLight 650]

Product Datasheets

COA

Certificate of Analysis

SDS

Product Specific Notices for DOK2 Antibody (OTI1A4) [DyLight 650]

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