DOK2 Antibody (OTI1A4) [mFluor Violet 610 SE] [NBP2-71407MFV610] - Vial of mFluor Violet 610 conjugated antibody. mFluor Violet 610 is optimally excited at 421 nm by the Violet laser (405 nm) and has an emission maximum of 613 nm.

Applications for DOK2 Antibody (OTI1A4) [mFluor Violet 610 SE]

Application

Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: DOK2

Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. DOK2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. DOK2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung. Expression of bcr/abl induces additional tyrosine phosphorylation of the DOK1 and DOK2 proteins and their association with Ras-GAP. Thus, it is suspected that DOK association regulates GAP activity toward Ras and that the DOK proteins serve as mediators of bcr-abl signaling. The role of DOK proteins in bcr-abl regulation may also be implicated in chronic myelogenous leukemia (CML), which is characterized by a Philadelphia chromosome translocation t(9;22). Such a mutation would result in a p210-bcr/abl chimeric protein-tyrosine kinase which has been found in many CML cases.

Alternate Names

docking protein 2, docking protein 2, 56kD, docking protein 2, 56kDa, Dok-2, Downstream of tyrosine kinase 2, p56(dok-2), P56DOK, p56dok-2

Gene Symbol

DOK2

Additional DOK2 Products

Product Documents for DOK2 Antibody (OTI1A4) [mFluor Violet 610 SE]

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for DOK2 Antibody (OTI1A4) [mFluor Violet 610 SE]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

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Flow Cytometry

DOK2 Antibody (OTI1A4) [mFluor Violet 610 SE]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-71407MFV610

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

Concentration

View all DOK2 Antibodies »

Product Specifications

Immunogen

Clonality

Host

Isotype

Scientific Data Images for DOK2 Antibody (OTI1A4) [mFluor Violet 610 SE]

DOK2 Antibody (OTI1A4) [mFluor Violet 610 SE] [NBP2-71407MFV610] -

Applications for DOK2 Antibody (OTI1A4) [mFluor Violet 610 SE]

Flow Cytometry

Immunocytochemistry/ Immunofluorescence

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

Concentration

Shipping

Stability & Storage

Background: DOK2

Alternate Names

Gene Symbol

Additional DOK2 Products

Product Documents for DOK2 Antibody (OTI1A4) [mFluor Violet 610 SE]

Product Datasheets

COA

Certificate of Analysis

SDS

Product Specific Notices for DOK2 Antibody (OTI1A4) [mFluor Violet 610 SE]

CONTACT INFORMATION

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