Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. DOK2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. DOK2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung. Expression of bcr/abl induces additional tyrosine phosphorylation of the DOK1 and DOK2 proteins and their association with Ras-GAP. Thus, it is suspected that DOK association regulates GAP activity toward Ras and that the DOK proteins serve as mediators of bcr-abl signaling. The role of DOK proteins in bcr-abl regulation may also be implicated in chronic myelogenous leukemia (CML), which is characterized by a Philadelphia chromosome translocation t(9;22). Such a mutation would result in a p210-bcr/abl chimeric protein-tyrosine kinase which has been found in many CML cases.

Alternate Names

docking protein 2, docking protein 2, 56kD, docking protein 2, 56kDa, Dok-2, Downstream of tyrosine kinase 2, p56(dok-2), P56DOK, p56dok-2

Gene Symbol

DOK2

Additional DOK2 Products

Product Documents for DOK2 Antibody (OTI1A4) [FITC]

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COA

SDS

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Product Specific Notices for DOK2 Antibody (OTI1A4) [FITC]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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DOK2 Antibody (OTI1A4) [FITC]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-71407F

Key Product Details

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Applications for DOK2 Antibody (OTI1A4) [FITC]

Flow Cytometry

Immunocytochemistry/ Immunofluorescence

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Background: DOK2

Alternate Names

Gene Symbol

Additional DOK2 Products

Product Documents for DOK2 Antibody (OTI1A4) [FITC]

Product Datasheets

COA

Certificate of Analysis

SDS

Product Specific Notices for DOK2 Antibody (OTI1A4) [FITC]

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