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Angiopoietin-like Protein 3/ANGPTL3 Products

Angiopoietin-like Protein 3 (ANGPTL3) is a secreted glycoprotein that is primarily expressed in the liver. Full length ANGPTL3 circulates in the plasma as do the proteolytically separated N- and C-terminal fragments containing the coiled coil domain and fibrinogen-like domains, respectively. ANGPTL3 directly inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), enzymes responsible for hydrolyzing circulating triglycerides and HDL phospholipids. It promotes an increase in circulating triglyceride levels without altering VLDL or HDL secretion or uptake. ANGPTL3 is upregulated by LXR agonists and downregulated by Insulin, Leptin, and agonists of TR beta or PPAR beta. Its fibrinogen-like domain interacts with Integrin alphaV beta3 to induce endothelial cell adhesion, migration, and neovascularization. ANGPTL3 also promotes the expansion of hematopoietic stem cells.

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108 results for "Angiopoietin-like Protein 3/ANGPTL3" in Products

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108 results for "Angiopoietin-like Protein 3/ANGPTL3" in Products

Angiopoietin-like Protein 3/ANGPTL3 Products

Angiopoietin-like Protein 3 (ANGPTL3) is a secreted glycoprotein that is primarily expressed in the liver. Full length ANGPTL3 circulates in the plasma as do the proteolytically separated N- and C-terminal fragments containing the coiled coil domain and fibrinogen-like domains, respectively. ANGPTL3 directly inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), enzymes responsible for hydrolyzing circulating triglycerides and HDL phospholipids. It promotes an increase in circulating triglyceride levels without altering VLDL or HDL secretion or uptake. ANGPTL3 is upregulated by LXR agonists and downregulated by Insulin, Leptin, and agonists of TR beta or PPAR beta. Its fibrinogen-like domain interacts with Integrin alphaV beta3 to induce endothelial cell adhesion, migration, and neovascularization. ANGPTL3 also promotes the expansion of hematopoietic stem cells.

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Applications: WB
Applications: BA, InhibAct
Applications: InhibAct
Applications: BA
Applications: IHC, WB
Reactivity: Human
Applications: IHC, WB, ELISA, ICC/IF
Reactivity: Human, Mouse, Rat

Recombinant Monoclonal Antibody

Applications: ELISA
Applications: IHC, WB
Reactivity: Human
Applications: IHC, WB, ELISA
Reactivity: Human
Applications: WB, ICC/IF
Reactivity: Human, Mouse, Rat

Recombinant Monoclonal Antibody

Applications: WB, ELISA, ICC/IF
Reactivity: Human
Applications: ELISA
Applications: ELISA, Flow, Func
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: ELISA, Flow, Func
Reactivity: Human

Recombinant Monoclonal Antibody

Catalog #: NBP3-42853
Applications: ELISA
Applications: WB, ELISA, ICC/IF
Reactivity: Human
Applications: WB, ELISA, ICC/IF
Reactivity: Human
Applications: WB, ELISA, ICC/IF
Reactivity: Human
Applications: WB, ELISA, ICC/IF
Reactivity: Human
Applications: WB, ELISA, ICC/IF
Reactivity: Human
Applications: ELISA, Flow, Func
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: ELISA, Flow, Func
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: ELISA, Flow, Func
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: ELISA, Flow, Func
Reactivity: Human

Recombinant Monoclonal Antibody

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