c-Abl Products
c-Abl (Abelson murine leukemia viral homolog 1) is a cytosolic member of the ABL subfamily, protein tyrosine kinase family of enzymes. It is ubiquitously expressed, and participates in multiple processes such as cell migration, actin reorganization, DNA damage response and apoptosis. Human c-Abl (I-B) is 1149 amino acids (aa) in length. It is myristoylated on Gly2 and contains one SH3 domain (aa 80-140), an SH2 domain (aa 146-236), a protein kinase region (aa 261-512), three NLS's (aa 620-634; 726-739; 778-791), one DNA-binding region (aa 888-988), an NES motif (aa 1109-1119) and an actin F-binding domain (aa 1120-1149). There is one alternate splice form (I-A) that contains a 26 aa substitution for the N-terminal 45 amino acids. In chronic myelogenous leukemia, c-Abl is fused to the Bcr gene product, resulting in the production of a constitutively active tyrosine kinase.
60 results for "c-Abl" in Products
60 results for "c-Abl" in Products
c-Abl Products
c-Abl (Abelson murine leukemia viral homolog 1) is a cytosolic member of the ABL subfamily, protein tyrosine kinase family of enzymes. It is ubiquitously expressed, and participates in multiple processes such as cell migration, actin reorganization, DNA damage response and apoptosis. Human c-Abl (I-B) is 1149 amino acids (aa) in length. It is myristoylated on Gly2 and contains one SH3 domain (aa 80-140), an SH2 domain (aa 146-236), a protein kinase region (aa 261-512), three NLS's (aa 620-634; 726-739; 778-791), one DNA-binding region (aa 888-988), an NES motif (aa 1109-1119) and an actin F-binding domain (aa 1120-1149). There is one alternate splice form (I-A) that contains a 26 aa substitution for the N-terminal 45 amino acids. In chronic myelogenous leukemia, c-Abl is fused to the Bcr gene product, resulting in the production of a constitutively active tyrosine kinase.
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western |
Highly potent pan-Src/Bcr-Abl inhibitor
| Alternate Names: | BMS-354825 |
| Chemical Name: | N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide |
| Purity: | ≥98% (HPLC) |
| Source: | E. coli |
| Accession #: | P00519.4 |
| Applications: | EnzAct |
Dual Src-Abl inhibitor; antiproliferative
| Alternate Names: | SKI-606 |
| Chemical Name: | 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile |
| Purity: | ≥99% |
Potent, selective Src family kinase inhibitor
| Chemical Name: | 1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity: | ≥98% |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 Monoclonal Clone #8E9 |
| Applications: | IHC, WB, ICC/IF, IP |
![Western Blot: c-Abl Antibody (8E9) [NBP2-49695]](https://resources.bio-techne.com/images/products/c-Abl-Antibody-8E9-Western-Blot-NBP2-49695-img0004.jpg "Western Blot: c-Abl Antibody (8E9) [NBP2-49695]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: c-Abl Antibody [NBP2-15631]](https://resources.bio-techne.com/images/products/c-Abl-Antibody-Western-Blot-NBP2-15631-img0009.jpg "Western Blot: c-Abl Antibody [NBP2-15631]")
Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit
| Chemical Name: | 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate |
| Purity: | ≥98% |
BCR-ABL1 kinase PROTAC® Degrader
| Chemical Name: | (2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(2-(4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)phenoxy)ethoxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
Src family kinase inhibitor; also inhibits c-Abl
| Alternate Names: | 1-NA-PP 1 |
| Chemical Name: | 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity: | ≥99% (HPLC) |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: c-Abl Antibody [NBP1-90289]](https://resources.bio-techne.com/images/products/c-Abl-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-90289-img0006.jpg "Immunocytochemistry/ Immunofluorescence: c-Abl Antibody [NBP1-90289]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: c-Abl Antibody [NBP1-90287]](https://resources.bio-techne.com/images/products/c-Abl-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-90287-img0004.jpg "Immunocytochemistry/ Immunofluorescence: c-Abl Antibody [NBP1-90287]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #PSH04-08 |
| Applications: | IHC, WB, ICC/IF, Flow |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #M209 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: c-Abl [p Tyr245] Antibody [NBP3-13326]](https://resources.bio-techne.com/images/products/c-Abl-[p-Tyr245]-Antibody-Western-Blot-NBP3-13326-img0003.jpg "Western Blot: c-Abl [p Tyr245] Antibody [NBP3-13326]")
Potent inhibitor of Abl T315l mutant and wild-type Abl kinases
| Chemical Name: | 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethyl-3-pyridinecarboxamide |
| Purity: | ≥98% |
Ras signaling inhibitor; inhibits Ack1 and GCK
| Chemical Name: | N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide |
| Purity: | ≥98% (HPLC) |
Potent EGFR and VEGFR inhibitor
| Chemical Name: | 6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Purity: | ≥98% |
Potent and selective Src tyrosine kinase family inhibitor; anticancer; antiviral; orally bioavailable
| Alternate Names: | AZD 0530 |
| Chemical Name: | N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![c-Abl [p Tyr412] Antibody](https://resources.bio-techne.com/images/products/nbp3-23318_rabbit-c-abl-p-tyr412-pab-19920231915414.jpg "Western Blot: c-Abl [p Tyr412] Antibody [NBP3-23318] -")
Potent multi-kinase and pan-Bcr-Abl inhibitor
| Chemical Name: | 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide |
| Purity: | ≥98% |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ELISA, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: c-Abl Antibody [NBP2-99737]](https://resources.bio-techne.com/images/products/c-Abl-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-99737-img0001.jpg "Immunocytochemistry/ Immunofluorescence: c-Abl Antibody [NBP2-99737]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ELISA, ICC/IF |
Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)
| Chemical Name: | N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide |
| Purity: | ≥98% (HPLC) |
Dual kinase inhibitor; inhibits PI 3-K family kinases
| Chemical Name: | 1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity: | ≥98% |
