Tie-2 Products
Tie-2, also known as Tek, is a transmembrane receptor tyrosine kinase (RTK) that functions as a receptor for Angiopoietin family proteins. It is expressed by embryonic and adult endothelial cells, hematopoietic stem cells, and a circulating population of proangiogenic monocytes. Tie-2 signaling is activated by Angiopoietins-1 and -4, while it can be either activated or inhibited by Angiopoietins-2 and -3.
Tie-2 plays an important role in maintaining vascular integrity by mediating endothelial cell-smooth muscle cell communication and inhibiting endothelial cell apoptosis. It is also required for the embryonic development of the endocardium. In addition, Tie-2 signaling mediates the quiescence of bone marrow stem cells in response to osteoblast-produced Angiopoietin-1. This quiescence is critical for maintaining an ongoing hematopoietic capability in the bone marrow.
Products:
174 results for "Tie-2" in Products
174 results for "Tie-2" in Products
Tie-2 Products
Tie-2, also known as Tek, is a transmembrane receptor tyrosine kinase (RTK) that functions as a receptor for Angiopoietin family proteins. It is expressed by embryonic and adult endothelial cells, hematopoietic stem cells, and a circulating population of proangiogenic monocytes. Tie-2 signaling is activated by Angiopoietins-1 and -4, while it can be either activated or inhibited by Angiopoietins-2 and -3.
Tie-2 plays an important role in maintaining vascular integrity by mediating endothelial cell-smooth muscle cell communication and inhibiting endothelial cell apoptosis. It is also required for the embryonic development of the endocardium. In addition, Tie-2 signaling mediates the quiescence of bone marrow stem cells in response to osteoblast-produced Angiopoietin-1. This quiescence is critical for maintaining an ongoing hematopoietic capability in the bone marrow.
Products:
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western, IHC, Block |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, IHC, CyTOF-ready, ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #83715 |
| Applications: | Flow |
| Sensitivity: | 40.2 pg/mL |
| Applications: | ELISA |
| Assay Range: | 125 - 8,000 pg/mL (Cell Culture Supernates, Tissue Homogenates, Serum, EDTA Plasma, Heparin Plasma) |
| Assay Range: | 156 - 10,000 pg/mL |
| Applications: | ELISA |
| Source: | NS0 |
| Accession #: | Q02763 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #83711 |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, Simple Western |
![Western Blot: Tie-2 AntibodyBSA Free [NBP1-69753]](https://resources.bio-techne.com/images/products/Tie-2-Antibody-Western-Blot-NBP1-69753-img0006.jpg "Western Blot: Tie-2 AntibodyBSA Free [NBP1-69753]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #83715 |
| Applications: | Flow |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #83708 |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #83715 |
| Applications: | WB, Flow |
| Applications: | ELISA |
| Source: | NS0 |
| Accession #: | CAA47857 |
| Applications: | Bind |
| Reactivity: | Zebrafish |
| Details: | Mouse IgG1 Monoclonal Clone #176222 |
| Applications: | WB, Block |
| Reactivity: | Zebrafish |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Block |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #83704 |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #83715 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0018-21G7 |
| Applications: | IHC, WB, ELISA |
![Western Blot: Tie-2 Antibody (MM0018-21G7)Azide and BSA Free [NB110-60986]](https://resources.bio-techne.com/images/products/Tie-2-Antibody-MM0018-21G7-Azide-and-BSA-Free-Western-Blot-NB110-60986-img0008.jpg "Western Blot: Tie-2 Antibody (MM0018-21G7)Azide and BSA Free [NB110-60986]")
| Reactivity: | Zebrafish |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #tek9 |
| Applications: | WB, ELISA, Flow, CyTOF-ready |
![Flow Cytometry: Tie-2 Antibody (tek9) - Azide and BSA Free [NBP1-18614]](https://resources.bio-techne.com/images/products/Tie-2-Antibody-tek9-Flow-Cytometry-NBP1-18614-img0014.jpg "Flow Cytometry: Tie-2 Antibody (tek9) - Azide and BSA Free [NBP1-18614]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #83715 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #83715 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #83715 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #83715 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #83715 |
| Applications: | Flow |
| Source: | NS0 |
| Accession #: | O73791 |
| Applications: | Bind |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal Clone #Regeneron patent anti-TIE-2 |
| Applications: | ELISA, Flow, Func |
| Applications: | AC |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal Clone #Regeneron patent anti-TIE-2 |
| Applications: | ELISA, Flow, Func |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal Clone #Regeneron patent anti-TIE-2 |
| Applications: | ELISA, Flow, Func |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0018-21G7 |
| Applications: | IHC, WB, ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0018-21G7 |
| Applications: | IHC, WB, ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0018-21G7 |
| Applications: | IHC, WB, ELISA |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, Simple Western |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, Simple Western |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #tek9 |
| Applications: | WB, ELISA, Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #tek9 |
| Applications: | WB, ELISA, Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #83715 |
| Applications: | WB, Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #B-B48 |
| Applications: | Flow, Func |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #B-B48 |
| Applications: | Flow, Func |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #B-B48 |
| Applications: | Flow, Func |