4-1BB Ligand/TNFSF9 Antibody (AP-MAB0875) [Janelia Fluor® 646]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-06697JF646

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Alexa Fluor 350

NBP1-06697AF350

Alexa Fluor 532

NBP1-06697AF532

Alexa Fluor 594

NBP1-06697AF594

Alexa Fluor 750

NBP1-06697AF750

DyLight 594

NBP1-06697DL594

Janelia Fluor 549

NBP1-06697JF549

mFluor Violet 450 SE

NBP1-06697MFV450

mFluor Violet 500 SE

NBP1-06697MFV500

mFluor Violet 610 SE

NBP1-06697MFV610

Forumulation

Catalog #

Azide and BSA Free

NBP1-06697

Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Mouse

Applications

Block/Neutralize, CyTOF-ready, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen, Immunoprecipitation

Label

Janelia Fluor 646

Antibody Source

Monoclonal Rat IgG₂ Clone # AP-MAB0875

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all 4-1BB Ligand/TNFSF9 Antibodies »

Product Specifications

Immunogen

BALB/c mouse B lymphoma cell line

Clonality

Monoclonal

Host

Rat

Isotype

IgG₂

Applications for 4-1BB Ligand/TNFSF9 Antibody (AP-MAB0875) [Janelia Fluor® 646]

Application

Recommended Usage

Block/Neutralize

Optimal dilutions of this antibody should be experimentally determined.

CyTOF-ready

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Frozen

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: 4-1BB Ligand/TNFSF9

CD137 exists on the cell surface as a monomer with a molecular mass of 30 kDa and as a dimer of 55 kDa. Human and mouse CD137 share 60% amino acid identity. CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen over stimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival.

Alternate Names

41BB Ligand, CD137L, TNFSF9

Gene Symbol

TNFSF9

Additional 4-1BB Ligand/TNFSF9 Products

Product Documents for 4-1BB Ligand/TNFSF9 Antibody (AP-MAB0875) [Janelia Fluor® 646]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for 4-1BB Ligand/TNFSF9 Antibody (AP-MAB0875) [Janelia Fluor® 646]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

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Flow Cytometry