- High Levels of Biological Activity: The biological activity of each protein is tested in an appropriate biological system to confirm that it meets our strict QC activity parameters before it is released to market.
- Lot-to-Lot Consistency: Minimal lot-to-lot variability is ensured by maintaining consistent manufacturing conditions and testing each new lot side-by-side with previous lots, so you don’t have to worry whether results will be reproducible over time.
- High Purity: The majority of our proteins have >95% purity and a guaranteed industry-leading endotoxin level of <0.1 EU/ug by the LAL method.
- Long-term Stability: The bioactivity and physical state of our proteins are monitored through multiple freeze/thaw cycles, so you can be confident that your protein will be stable over long periods of time. All proteins are shipped lyophilized or in specially optimized formulations to ensure that they reach you in perfect condition.
- Comprehensive Selection: Our catalog includes over 5,000 biologically active recombinant and natural proteins spanning 35 species, and more than 10,000 non-catalog proteins for multiple different research areas, allowing you to easily find the proteins that you need.
- Multiple Host Expression Systems, Tags, and Labels: Our proteins are produced in a variety of host expression systems and are either untagged or include a biotin, Fc, or His tag, or a fluorescent label to meet different experimental needs.
- Seamless Transition from RUO to GMP: Our Animal-free and GMP-grade proteins frequently originate from the same clone, sequence, and expression system as our traditional research-grade proteins, making the transition from basic research into process development and clinical manufacturing as efficient and seamless as possible.
- Bulk Proteins at Discounted Prices: We have the capacity and the expertise to scale up the production of any protein and we offer economical pricing on bulk orders.
- Custom Protein Capabilities: If you don’t see the protein that you need on our website, we offer custom protein services. From scratch protein development to customizing a protein from our catalog, our custom services team will work with you to create the product that fits your experimental needs.
- Custom Bottling Options: If your research requires a special formulation or size, custom bottling options are available.
- Expert Customer Support Assistance: Almost all of our proteins are manufactured in-house, allowing us to maintain complete control over the quality of our products. If you have any questions about our products, our protein scientists and highly trained technical service team are always available to assist you.
Featured Protein Products
Avi-tag and Amine-Labeled Biotinylated Proteins
Avi-tag and Amine-Labeled Biotinylated Proteins
Biotinylated proteins can be powerful tools for assessing protein-protein interactions or screening antibody or small molecule libraries for potential therapeutics. Our products provide the performance and consistency needed to advance your drug discovery research.
Cytokines and Growth Factors
Cytokines and Growth Factors
Achieve optimal cell culture conditions with R&D SystemsTM cytokines and growth factors. Our stringent production and purification standards ensure that our products will deliver superior performance and consistent results.
Animal-Free Preclinical Proteins
Animal-Free Preclinical Proteins
Save time and resources by starting your preclinical studies with Animal-free proteins. We utilize identical systems to manufacture our Animal-free and GMP-grade proteins, ensuring a seamless transition into clinical manufacturing.
Featured Literature: IL-2 Heat Stable Agonist Protein Application Note
Explore the benefits of culturing your T cells or tumor-infiltrating lymphocytes (TILs) with our new IL-2 Heat Stable Agonist Protein. Engineered using artificial intelligence (AI), this protein has enhanced stability, enabling it to withstand high temperatures and extended culture durations.
Proteins by Application or Research Area
Fluorokines™ Fluorescent-Labeled Proteins
Utilize our wide selection of fluorescent-labeled proteins to evaluate CAR expression on CAR-T or CAR-NK cells, detect immune checkpoint receptors, or identify SARS-CoV-2-responsive cells. Fluorokines are highly specific and allow target molecules to be directly stained and detected by flow cytometry.
Customer Success Stories
Pluripotent Stem Cell Core Children's Hospital of Phila.
Stem Cell Core Facility | Columbia University Medical School
iPSC Core Facility | University of Pennsylvania
Custom Protein Services
If you can’t find the protein that you need on our website, contact us. From scratch protein development to customizing a protein from our catalog, our experienced custom protein services team will work with you to create the protein that fits your experimental needs.
Background Information
R&D Systems: The Most Trusted Source for Recombinant Proteins
Bio-Techne offers more than 5,000 R&D Systems® recombinant proteins for a variety of different research areas including immunology, cancer, development, neuroscience, and stem cells. With over 30 years of experience, R&D Systems’ rigorous in-house testing and quality control specifications ensure that our recombinant proteins will provide industry-leading bioactivity and purity, lot-to-lot consistency, and low endotoxin levels. As more than 95% of the proteins in our catalog are manufactured in-house, we maintain complete control over the quality of our products and the satisfaction of our customers, which is our number one priority.
To guarantee that each protein meets our customers’ high standards, we fully assess and report the specifications of each protein on our datasheets, including the activity, endotoxin level, and purity. The bioactivities of our proteins are assessed using a variety of different assays depending on the protein being tested. These include cell proliferation, chemotaxis, or cytokine secretion assays, enzymatic assays, functional ELISAs, and surface plasmon resonance (SPR). N-terminal sequence analysis is also performed for each recombinant protein to confirm that the protein produced matches the expected sequence, and the bioactivity and physical state of our proteins are monitored over long periods of time. Freeze/thaw cycles are carried out to ensure that the buffer provides for long-term stability. Additionally, we evaluate lot-to-lot consistency so that researchers don’t have to worry about whether or not their experiments will be reproducible over time. Multiple lots with matching specifications are created for all new proteins and each new lot is tested side-by-side with previous lots to ensure that the new lots display the same level of bioactivity and purity as the previous lots. Each new lot is also tested to make sure that it meets our expectations for endotoxin specifications, which is an industry-leading <0.1 EU/µg. Finally, all of our recombinant proteins are specially formulated for the best stability and are lyophilized from a sterile filtered solution. If our documentation fails to address any questions that you may have about our products, our protein scientists and highly trained technical service team at R&D Systems are always available to assist you.
Our catalog includes recombinant proteins for multiple different species, that are either untagged or have a biotin, Fc, or His tag. We also offer an expanding line of Avi-tag biotinylated proteins. Our standard recombinant proteins are available without or with a carrier protein, which is typically bovine serum albumin (BSA) at a concentration of 50 µg BSA per 1 µg of protein. The presence of the carrier protein gives the lyophilized protein greater stability, maximizes recovery upon reconstitution, and allows easy handling and storage. In addition to the wide selection of proteins that are manufactured under standard conditions, our portfolio also includes R&D Systems Animal-Free™ and GMP-grade recombinant proteins, and custom protein development services.