RNAscope™ In Situ Hybridization

• No antibody available.
• Low expressing antigens.
• Poor antibody performance.
• Secreted proteins including cytokines, chemokines, and growth factors.

• Any expressed mRNA, non-coding RNA, ASO, siRNA, miRNA, splice variant.
• RNA and protein co-detection.
• Viruses and microbial agents.

• CAR-T and TCR-T cells.
• Gene therapy vectors (AAV).
• Transgenes and reporters.

Most widely used assay for detection of mRNAs, ncRNAs, viruses, bacteria and engineered cells and vectors. Designed for RNA targets of > 300 nucleotides.

Ideal for RNA targets 50-300 nucleotides in length,  BaseScope provides an excellent solution for detection of exon junctions/splice variants and short or highly homologous RNA sequences.

Designed to detect short RNAs of 17-50 nucleotides including small non-coding RNAs siRNAs, ASOs, and miRNAs.

Characterize RNA biomarkers in anatomical context using selected chromogens.

See changes in gene expression in spatial context at subcellular resolution with multiplex fluorescent imaging.

Visualize changes in cell phenotypes and function with protease-free same-slide multiomics workflows.

Explore automated RNAscope, BaseScope™, and miRNAscope™ assays for use with the Leica BOND RX System by Leica Biosystems

Learn more about RNAscope and  BaseScope assays available for use with the Roche DISCOVERY ULRA.

See how you can easily visualize up to 12 RNAscope targets and up to 24 protein targets using RNAscope HiPlex Pro on the Lunaphore COMET.

Reveal new insights in cell phenotype and function with confidence.

Qualify biomarkers for disease progression, patient stratification, and clinical endpoints with high precision.

Visualize AAV vector and ASO/siRNA biodistribution, cellular tropism, and transduction efficiency in spatial context.

Quantify infiltration and cellular activation of engineered cells in cancer and diseased tissues.

If you don’t find the probe you need in our online catalog, our expert probe team can create a custom design for you. Easily select from a wide range of different probe types to achieve your project goals.

To support your discovery, preclinical, and clinical studies, we offer end-to-end, GCLP-compliant in situ hybridization (ISH) assay services from sample procurement to data and image analysis.